MicroRNA、Apelin、Galectin-3和Endocan等血清学指标与动脉粥样硬化斑块稳定性关系的研究进展

Research progress on the relationship between microRNA, apelin, galectin-3, endocan and atherosclerotic plaque stability

动脉粥样硬化斑块的形成是冠心病发病的主要机制,斑块的不稳定性与急性冠状动脉综合征的发生有明显的相关性。目前检测斑块的不稳定性主要通过血管内超声、光学相干断层成像等侵入性操作。而MicroRNA、Apelin、Galectin-3、Endocan等血清学检查指标与斑块的稳定性有直接相关性,可以作为生物学指标预测斑块的稳定性。文章对MicroRNA、Apelin、Galectin-3、Endocan等血清学指标与动脉粥样硬化斑块稳定性关系的研究进展作一综述。

The formation of atherosclerotic plaque is the main mechanism of coronary heart disease. The instability of plaque is significantly related to the occurrence of acute coronary syndrome. At present, the detection of plaque instability is mainly through intravascular ultrasound, optical coherence tomography and other invasive operations. The microRNA, apelin, galectin-3, endocan and other serological indicators are directly related to the stability of plaques, which can be used as biological indicators to predict the stability of plaques. This article reviews the research progress on the relationship between microRNA, apelin, galectin-3, endocan and atherosclerotic plaque stability.