MSCs来源外泌体在创面修复中的研究进展

Progress of mesenchymal stem cells derived exosomes in wound repair

目的总结近年来MSCs来源外泌体(exosomes,EXOs)在创面修复中的研究进展。方法广泛查阅国内外有关MSCs-EXOs在创面修复中作用的文献,总结分析MSCs-EXOs在创面修复过程中的作用机制及其临床应用前景。结果 MSCs-EXOs在创面愈合过程中可抑制早期的炎性反应,促进血管新生和上皮细胞的增殖与迁移,后期调控胶原合成并抑制瘢痕增生。与MSCs相比,MSCs-EXOs具有高稳定性、易于储存、不易致瘤、无需增殖、便于定量使用等优点,有着广阔的临床应用前景。结论 MSCs-EXOs能够促进创面修复,且有希望发展成为临床上一种促进急性或慢性创面修复的产品。

Objective To summarize the research progress of mesenchymal stem cells derived exosomes(MSCs-EXOs) in wound repair in recent years. Methods The literature about the role of MSCs-EXOs in wound repair at home and abroad was extensively consulted. The mechanism of MSCs-EXOs in wound repair and its clinical application prospects were summarized and analyzed. Results MSCs-EXOs can inhibit early inflammatory reaction, promote angiogenesis, proliferation, and migration of epithelial cells, regulate collagen synthesis, and inhibit scar proliferation in the later stage of wound healing. Compared with MSCs, MSCs-EXOs have many advantages, such as high stability, easy storage, non-tumorigenicity, no proliferation, easy quantitative use, and so on. It has broad clinical application prospects.Conclusion MSCs-EXOs can promote wound repair and hopefully develop into a clinical product to promote the repair of acute or chronic wounds.