Notch信号通路与支气管肺发育不良被引量：2

Notch signaling pathway and bronchopulmonary dysplasia

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摘要支气管肺发育不良(bronchopulmonary dysplasia,BPD)是各种理化因素造成不成熟肺的损伤及损伤后异常修复的一种慢性肺部疾病,近年来已成为新生儿重症监护室最棘手的问题之一。Notch信号通路是一条在胚胎发育中起调控作用的保守途径。Notch信号生物学效应广泛,通过介导细胞之间的相互作用,精细地调控细胞生长、发育、凋亡等过程。该文就Notch信号通路与BPD在肺发育、高氧肺损伤和肺再生修复中可能存在的关系予以综述。 Bronchopulmonary dysplasia(BPD)is a chronic lung disease caused by various physical and chemical factors, which causes immature lung injury and abnormal repair after injury.In recent years, BPD has become one of the most difficult problems in neonatal intensive care unit.Notch signaling pathway is a conservative pathway that plays a regulatory role in embryonic development.Notch signaling pathways have a wide range of biological effects.By mediating cell-to-cell interactions, Notch signals can finely regulate the growth, development and apoptosis of cells.This article reviews the relationship between Notch signaling pathway and BPD in lung development, hyperoxia-induced lung injury and lung regeneration.

作者邓健(综述) 王少华(审校) Deng Jian;Wang Shaohua(Department of Pediatrics, Women and Children Health Institute Futian Affiliated to University of South China, Shenzhen 518045, China)

机构地区南华大学深圳市福田区妇幼保健院儿科

出处《国际儿科学杂志》 2019年第4期277-280,共4页 International Journal of Pediatrics

基金 2016年深圳市科技创新委员会资助项目(JCYJ20160429090648512).

关键词 NOTCH信号通路支气管肺发育不良高氧肺损伤 Notch signaling pathway Bronchopulmonary dysplasia Hyperoxia lung injury

分类号 R457.7 [医药卫生—治疗学]

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参考文献3

1李龙辉,王少华.细胞信号通路与支气管肺发育不良[J].国际儿科学杂志,2016,43(9):684-688. 被引量：2
2黄海云,李晓东.支气管肺发育不良发病机制和防治研究进展[J].国际儿科学杂志,2016,43(9):692-695. 被引量：11
3侯阿娜,富建华,薛辛东.高氧暴露对新生鼠Ⅱ型肺泡上皮细胞转分化水平的调节作用[J].国际儿科学杂志,2017,44(4):281-285. 被引量：4

二级参考文献41

1容志惠,常立文,钱莉玲,李文斌.支气管肺发育不良不同时期基质金属蛋白酶、基质金属蛋白酶特异性组织抑制物及核转录因子κB表达变化[J].实用儿科临床杂志,2005,20(5):440-442. 被引量：13
2SampathV, GarlandJS,HelblingD,et al.Anti oxidant response genes sequence variants and BPD susceptibility in VLBW infants[J].Pediatr Res,2015,77(3):477-483.DOI:10.1038/pr.2014.200.
3WangX,LiW,LiuW,et al.GSTM1 and GSTT1 gene polymorphisms as major risk factors for bronchopulmonary dysplasia in a Chinese Han population[J].Gene,2014,533(1):48-51.DOI:10.1016/j.gene.2013.10.004.
4AmbalavananN,CottenCM,PageGP,et al.Integrated genomic analyses in bronchopulmonary dysplasia[J].J Pediatr,2015,166(3):531-537.DOI:10.1016/j.jpeds.2014.09.052.
5RyanRM,AhmedQ,LakshminrusimhaS.Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia[J].Clin Rev Allergy Immunol,2008,34(2):174-190.DOI:10.1007/s12016-007-8031-4.
6ShahJ,JefferiesAL,YoonEW,et al.Risk factors and outcomes of late-onset bacterial sepsis in preterm neonates born at < 32 weeks′ gestation[J].Am J Perinatol,2015,32(7):675-682.DOI:10.1055/s-0034-1393936.
7FloenMJ,ForredBJ,BloomEJ,et al.Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia[J].Free Radical Bio Med,2014,75(0):167-177.DOI:10.1016/j.freeradbiomed.2014.07.023.
8ThakurVS,LiangYW,LingappanK,et al.Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo{a}pyrene[J].Toxicol Lett,2014,230(2):322-332.
9ZhaoL,ZhuangJ,ZangN.Prenatal nicotinic exposure upregulates pulmonary C-fiber NK1R expression to prolong pulmonary C-fiber-mediated apneic response[J].Toxicol Appl Pharmacol,2016,290:107-115.DOI:10.1016/j.taap.2015.10.023.
10HijaziA,GuanH,CerneaM.Prenatal exposure to bisphenol A disrupts mouse fetal lung development[J].FASEB J,2015,29(12):4968-4977.DOI:10.1096/fj.15-270942.