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Notch信号通路与支气管肺发育不良 被引量:2

Notch signaling pathway and bronchopulmonary dysplasia
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摘要 支气管肺发育不良(bronchopulmonary dysplasia,BPD)是各种理化因素造成不成熟肺的损伤及损伤后异常修复的一种慢性肺部疾病,近年来已成为新生儿重症监护室最棘手的问题之一。Notch信号通路是一条在胚胎发育中起调控作用的保守途径。Notch信号生物学效应广泛,通过介导细胞之间的相互作用,精细地调控细胞生长、发育、凋亡等过程。该文就Notch信号通路与BPD在肺发育、高氧肺损伤和肺再生修复中可能存在的关系予以综述。 Bronchopulmonary dysplasia(BPD)is a chronic lung disease caused by various physical and chemical factors, which causes immature lung injury and abnormal repair after injury.In recent years, BPD has become one of the most difficult problems in neonatal intensive care unit.Notch signaling pathway is a conservative pathway that plays a regulatory role in embryonic development.Notch signaling pathways have a wide range of biological effects.By mediating cell-to-cell interactions, Notch signals can finely regulate the growth, development and apoptosis of cells.This article reviews the relationship between Notch signaling pathway and BPD in lung development, hyperoxia-induced lung injury and lung regeneration.
作者 邓健(综述) 王少华(审校) Deng Jian;Wang Shaohua(Department of Pediatrics, Women and Children Health Institute Futian Affiliated to University of South China, Shenzhen 518045, China)
出处 《国际儿科学杂志》 2019年第4期277-280,共4页 International Journal of Pediatrics
基金 2016年深圳市科技创新委员会资助项目(JCYJ20160429090648512).
关键词 NOTCH信号通路 支气管肺发育不良 高氧肺损伤 Notch signaling pathway Bronchopulmonary dysplasia Hyperoxia lung injury
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