益生菌与早产儿脑白质损伤关系的研究进展

Advances in the relationship between probiotics and white matter damage of premature infant

益生菌在促进营养物质的吸收、参加免疫调节反应、抑制炎性细胞因子等方面有重要作用。早产儿脑白质损伤是早产儿脑损伤主要的病理形式,常并发认知、听力障碍及智力低下、脑性瘫痪等。最新发现益生菌可以保证营养摄入均衡、提高机体免疫力,抑制炎性因子释放、减轻神经细胞水肿,增强抗氧化酶活性及清除氧自由基,抑制兴奋性氨基酸活性、减轻兴奋毒性作用,以及通过微生物-肠-脑轴促进早产儿脑白质损伤后神经细胞功能的恢复。该文就益生菌在早产儿脑白质损伤后的保护及修复等方面作一综述。

Probiotics is important to promote the absorption of nutrients, to respond to immune response, to suppress inflammatory cytokines and so on.Premature infant white matter damage is the main pathological form of preterminfant brain injury, and it is often complicated with cognitive, hearing impairment, mental retardation, cerebral palsy, etc.The latest finding is that probiotics can ensure balanced nutrition intake, improve body immunity, inhibit inflammatory factor release, reduce nerve cell edema, enhance antioxidant enzyme activity and oxygen free radical scavenging, inhibit excitatory amino acid activity, reduce excitatory toxicity, and promote the recovery of function of nerve cells in white matter damage in premature infants through microbiota-gut-brain axis.This article reviews the protection and repair of probiotics in premature infants with white matter damage.