摘要
过氧化物酶体增殖物激活受体(PPARs)是一类由受体激活的转录因子,可以调节糖、脂质代谢,参与机体的炎症反应、细胞凋亡和动脉粥样硬化(AS)等疾病过程。PPARs可分为过氧化物酶体增殖物激活受体α(PPARα)、过氧化物酶体增殖物激活受体β(PPARβ)和过氧化物酶体增殖物激活受体γ(PPARγ),目前PPARγ的研究最为广泛,PPARγ的翻译后修饰主要包括磷酸化、乙酰化、泛素化和小泛素相关修饰物化(SUMO化)等。近年来研究发现,PPARγ及其翻译后的磷酸化修饰与动脉粥样硬化、糖尿病、肿瘤等疾病密切相关。
Peroxisome proliferator-activated receptors (PPARs) is a class of receptor-activated transcription factors that regulate sugar, lipid metabolism, and participate in the body′s inflammatory response, apoptosis,and atherosclerosis (AS).PPARs can be divided into peroxisome proliferator-activated receptor α(PPARα), peroxisome proliferator-activated receptor β(PPARβ) and peroxisome probiferator-activated receptor (PPARγ). Currently, PPARγ is the most widely studied, post-translational modification of PPARγ mainly includes phosphorylation, acetylation, ubiquitination and small ubiquitin-related modification (SUMO). In recent years, it has been found that PPARγ and its phosphorylation modification is closely related to diseases such as atherosclerosis, diabetes and tumor.
作者
王静
陈红
孙晓
娄宪芝
佟浩
张曼
WANG Jing;CHEN Hong;SUN Xiao;LOU Xian-zhi;TONG Hao;ZHANG Man(Department of Internal Medicine, Affiliated Central Hospital of Shenyang Medical College, Liaoning Province, Shenyang,110024, China;Department of Internal Medicine, Shenyang Maternal and Child Hospital, Liaoning Province, Shenyang,110121, China;Department of Tissue Engineering, China Medical University, Liaoning Province, Shenyang,110003, China)
出处
《中国当代医药》
2019年第12期30-32,36,共4页
China Modern Medicine
基金
辽宁省自然科学基金指导计划项目(20170540869
20170540881)
辽宁省沈阳市科技计划项目(17-230-9-70
17-230-9-32)