去甲基化药物联合CAG方案治疗老年急性髓系白血病的效果

Effect of demethylated drugs combined with CAG regimen in the treatment of acute myeloid leukemia in the elderly

目的探讨去甲基化药物联合CAG方案治疗老年急性髓系白血病的效果。方法回顾性分析我院2013年6月～2018年6月收治的62例老年急性髓系白血病患者,根据治疗方法的不同分为对照组(34例)与观察组(28例)。对照组患者接受CAG方案(阿克拉霉素+阿糖胞苷+粒细胞集落刺激因子)治疗,观察组患者接受去甲基化药物+CAG方案治疗,比较两组患者的临床治疗效果及不良反应情况。结果观察组患者的治疗总有效率为75.00%,明显高于对照组的55.88%,差异有统计学意义(P<0.05)。两组患者的肺部感染、心力衰竭、恶心呕吐、肝功能损伤、血小板减少及粒细胞减少发生率比较,差异无统计学意义(P>0.05)。结论对老年急性髓系白血病患者予以去甲基化药物+CAG方案治疗的临床效果较好,且安全性可靠,未增加患者出现并发症的概率,值得临床推广应用。

Objective To explore the effect of demethylation agents combined with CAG regimen in the treatment of acute myeloid leukemia in the elderly. Methods A total of 62 cases of elderly patients admitted for acute myeloid leukemia in our hospital from June 2013 to June 2018 were retrospectively analyzed, according to the different treatment methods, they were divided into the control group (34 cases) and the observation group (28 cases). The patients in the control group were treated with CAG regimen, while those in the observation group were treated with demethylation drugs plus CAG regimen (Aclacinomycin+Cytarabine+Granulocyte Colony Stimulating Factor). The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 75.00%, which was significantly higher than 55.88% of the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of pulmonary infection, heart failure, nausea and vomiting, liver function damage, thrombocytopenia and granulocytopenia between the two groups (P>0.05). Conclusion The clinical effect of demethylation drug plus CAG regimen in the treatment of elderly patients with acute myeloid leukemia is good, and it is safe and reliable. It does not increase the probability of complications. It is worthy of clinical promotion and application.