PET/CT显像在卵巢癌患者术后复发与转移中的应用效果

Application of PET/CT imaging in recurrence and metastasis of ovarian cancer after operation

目的为了提高临床对卵巢癌术后复发与转移的检出率,分析PET/CT显像在卵巢癌患者术后复发与转移中的应用效果。方法选取2016年7月～2017年7月在本院手术治疗且术后病理诊断为卵巢癌的47例患者作为研究对象,所有患者均在术后随访过程中行PET/CT检查和常规影像学检查(如CT、超声等),并经再次手术后病理学检查、多种影像学检查和临床随访而确诊术后复发或转移,比较PET/CT检查与常规检查方法的敏感性、特异性、准确性及术后转移或复发患者血清中的CA125水平检出阳性率。结果 PET/CT显像对卵巢癌术后复发与转移灶检测的敏感性、特异性、准确性分别为80.13%、79.55%、83.22%,高于常规影像学检查的68.55%、58.65%、63.86%,差异有统计学意义(P<0.05);术后转移或复发患者血清中CA125水平升高者37例(78.72%),PET/CT显像阳性率为94.59%(35/37),高于常规影像学检查的78.38%(29/37),差异有统计学意义(P<0.05)。结论卵巢癌术后考虑复发与转移的患者行PET/CT显像检测较常规影像学检查方法具有准确性高、敏感性好、特异性强的优点,对于同时伴有血清CA125升高的患者,应用PET/CT检测其灵敏度显著高于常规影像学检查方法 ,值得临床应用。

Objective In order to improve the detection rate of recurrence and metastasis of ovarian cancer after operation, and to analyze the application effect of PET/CT imaging in recurrence and metastasis of ovarian cancer after operation. Methods A total of 47 patients with ovarian cancer who underwent surgery in our hospital from July 2016 to July 2017 were selected as the study subjects. All patients underwent PET/CT examination and routine imaging examination (such as CT, ultrasound, etc.) during the follow-up period, and were confirmed to have recurrence or metastasis after reoperation by pathological examination, multiple imaging examinations and clinical follow-up. Sensitivity, specificity, accuracy, and positive rate of serum CA125 level in patients with metastasis or recurrence after operation were compared by PET/CT and routine methods. Results The sensitivity, specificity and accuracy of PET/CT imaging in detecting recurrence and metastasis of ovarian cancer after operation were 80.13%, 79.55% and 83.22% respectively, which were higher than 68.55%, 58.65% and 63.86% of routine imaging examination (P<0.05). Serum CA125 level increased in 37 patients with metastasis or recurrence after operation (78.72%), the positive rate of imaging was 94.59%(35/37), which was higher than 78.38%(29/37) of routine imaging examination, and the difference was statistically significant (P<0.05). Conclusion PET/CT imaging for patients with ovarian cancer considering recurrence and metastasis after operation has the advantages of higher accuracy, better sensitivity and specificity than routine imaging examination. For patients with elevated serum CA125, it should be used. The sensitivity of PET/CT is significantly higher than that of conventional imaging methods, which is worthy of clinical application.