HIV感染合并骨梗死的MRI动态观察

Dynamic observation of MRI in HIV-infected patients with bone infarction

目的:探讨高效联合抗逆转录病毒疗法(HAART)治疗时间与骨梗死面积的相关性。方法:回顾性分析16例行HAART治疗9~32个月的HIV感染患者骨梗死MRI资料,统计分析HAART治疗时间与骨梗死的相关性。结果:16例骨梗死均发生在股骨下段、胫骨上段;均呈双侧股骨下段、胫骨上段对称性发生;均呈多发类椭圆形地图板块样改变,边界清楚,9例见双边征。随着HAART治疗时间的增加,16例骨梗死面积进行性扩大,两者呈正相关(P<0.05)。结论:HIV感染合并骨梗死的面积与HAART治疗时间呈正相关。

Objective:16 patients with HIV combined with bone infarction were followed up to explore the correlation between HAART therapy and bone infarction. Methods:MRI data of 16 HIV-infected patients with bone infarction treated with HAART for 9 to 32 months were retrospectively analyzed. The correlation between the duration of HAART treatment and bone infarction was analyzed. Results:16 cases of bone infarction occurred in the lower femur and upper tibia. 16 cases of bone infarction all showed the symmetry of the lower femur and the upper tibia. The imaging manifestations of 16 cases of bone infarction were as follows:multiple oval-like map plate-like changes,clear boundary,and "bilateral sign". Follow-up observation showed that with the prolongation of HAART treatment course,the range of bone infarction was progressively expanded in 16 patients. Statistical analysis showed that 16 cases were positively correlated with the course of HAART treatment(P< 0.05). Conclusions:The progression of bone infarction of HIV-infected patients is positively correlated with the course of HAART treatment.