正念减压疗法对乳腺癌患者炎性标志物水平的影响

Effect of mindfulness-based stress reduction therapy on levels of inflammatory markers in patients with breast cancer

目的探讨正念减压疗法对乳腺癌患者血液炎性标志物水平的影响。方法选取2015年2月至2018年2月本院收治的170例乳腺癌患者为研究对象,将其随机等分为试验组和对照组。对照组接受常规护理,试验组在常规护理的基础上接受为期6周的正念减压疗法。分别于干预前,干预后第6周、第12周采集患者的静脉血检测血液中肿瘤坏死因子α(TNFα)以及白介素-6(IL-6)的浓度。结果干预前试验组TNFα浓度、IL-6与对照组比较差异无统计学意义(P> 0. 05),干预后6,12周TNFα,IL-6浓度高于对照组(P <0. 05)。结论正念减压疗法对乳腺癌患者炎性标志物水平有影响,主要表现为干预后TNFα浓度与IL-6浓度升高。TNFα浓度与IL-6浓度可作为评价正念减压疗法效果的客观生理指标之一。

Objective To explore the effect of mindfulness-based stress reduction therapy on levels of blood inflammatory markers in patients with breast cancer.Methods To select 170 cases of patients with breast cancer who were admitted to our hospital from February 2015 to February 2018 as the study subjects.They were divided into experimental group and control group with the same number of patients randomly.The control group was given routine nursing,while the experimental group was given a 6-week mindfulness-based stress reduction therapy on the basis of routine nursing.The venous bloods of the patients were collected before the intervention as well as at the 6th week and the 12th week after the intervention to detect the concentrations of tumor necrosis factor alpha(TNFα)and interleukin-6(IL-6)in the blood.Results Before the intervention,there was no statistical significance in the difference of comparison in the concentrations of TNFαand IL-6 between the experimental group and the control group(P>0.05).At the 6th week and 12th week after the intervention,TNFαand IL-6 concentrations of the experimental group were higher than that of the control group(P<0.05).Conclusion Mindfulness-based stress reduction therapy has an effect on the level of inflammatory markers in breast cancer patients.It mainly represented by the increase of TNFαconcentration and IL-6 concentration after intervention.Therefore,TNFαconcentration and IL-6 concentration can be used as one of the objective physiological indicators for evaluating the effect of mindfulness-based stress reduction therapy.