影响上皮性卵巢癌患者无瘤生存期的临床因素

Clinical Factors Affecting Tumor-free Survival in Patients with Epithelial Ovarian Cancer

目的探讨影响复发性卵巢癌患者无瘤生存期(DFI)的临床因素.方法通过对复发性卵巢癌患者临床资料的回顾性分析,确定可能影响复发性卵巢癌患者DFI的危险因素.结果单因素分析结果表明:首次术后残余病灶直径、临床分期、组织学分级、化疗疗程之间DFI差异具有统计学意义(P<0.05).多因素分析结果表明:首次术后残留病灶直径、临床分期、组织学分级及化疗疗程多因素分析结果 P分别为0.03,0.04,0.35,0.72.结论首次术后残余病灶直径、临床分期、组织学分级、化疗疗程是影响卵巢癌的危险因素;首次术后残留病灶直径、临床分期是影响复发性卵巢癌妇女无瘤生存期的独立危险因素.

Objective To investigate the clinical factors affecting the tumor-free survival(DFI)of recurrent ovarian cancer.Method Through retrospective analysis of clinical data of patients with recurrent ovarian cancer,the risk factors affected DFI in patients with analysis recurrent ovarian cancer were identified.Results The results of single factor showed that the difference of DFI among the first postoperative residual lesion diameter,clinical stage,histological grade and chemotherapy course were statistically significant(P<0.0 5).Multivariate analysis showed that P values of the residual diameter,clinical stage,histological grade and chemotherapy course of the first postoperative residual were 0.03,0.04,0.35 and 0.72,respectively.Conclusion The diameter of first postoperative residual lesion,clinical stage,histological grade and chemotherapy course are risk factors for ovarian cancer.The diameter and clinical stage of residual lesions are the independent risk factors for tumor-free survival in women with recurrent ovarian cancer.