丁香柿蒂代赭石联合治疗中风后顽固性呃逆临床观察

Clinical Observation on Intractable Hiccup after Stroke with Combined Therapy of Syzygium aromaticum,Persimmon calyx and Red Ochre

目的探讨联合应用丁香、柿蒂、代赭石治疗中风后顽固性呃逆的临床效果,并对其不良反应进行研究.方法3组患者均以对症治疗为基础,后续按方案实施.治疗1组:丁香10 g,柿蒂10 g,代赭石10 g.治疗2组:丁香15 g,柿蒂15 g,代赭石15 g.治疗3组(对照组):甲氧氯普胺(胃复安) 10 mg口服,3次/d,或甲氧氯普胺(胃复安) 10 mg肌肉注射,1次/d.结果治疗7 d后,1组总有效率为85.37%,2组为93.22%,对照组为78.91%,治疗1组、治疗2组与对照组比较差异具有统计学意义(P<0.05).治疗12 d后,与对照组比较,呃逆症状治疗2组改善更为明显,差异具有统计学意义(P<0.05).3组患者药物不良反应发生率差异无统计学意义(P>0.05).结论联合应用丁香、柿蒂、代赭石治疗中风后顽固性呃逆为一种安全且有效的方法.

Objective To make clinical effect on intractable hiccup after stroke with the combined therapy of Syzygium aromaticum,Persimmon calyx and Red Ochre and study the adverse drug reactions.Method Patients in three groups were treated with routine method:decrease of intracranial pressure,control of blood pressure and blood sugar and symptomatic treatment for stroke.The treating group I was treated with Syzygium aromaticum 10 g,Persimmon calyx 10 g and Red Ochre 10 g.The treating group II was treated with Syzygium aromaticum 15 g,Persimmon calyx 15 g and Red Ochre 15 g.The treating group III(control group)was given metoclopramide 10 mg for oral use additionally,3 times a day,or treated with metoclopramide 10 mg for intramuscular injection once a day.Results After 7 days of treatment,the total effective rate was 85.37%in group I,93.22%in group II,and 78.91%in control group.There was significant difference between the two groups compared with control group(P<0.05).On the 12th day of treatment,the improvement of hiccup symptom scores in treating group I was more distinct than that of the control group with statistical significance(P<0.05).There was no difference in the incidence of adverse drug reactions among three groups(P>0.05),and there was no statistical significance.Conclusion It is a safe and efficacy method to treat intractable hiccup after stroke with combined therapy of Syzygium aromaticum,Persimmon calyx and Red Ochre.