HIV感染与非HIV感染患者慢性根尖周炎的炎性因子及免疫功能对比

Comparison of Inflammatory Factors and Immune Function between HIV-infected and Non-HIV-infected Patients with Chronic Apical Periodontitis

目的:比较HIV感染和非HIV感染患者慢性根尖周炎的炎性因子及免疫功能的差异。方法:收集48例(24例HIV感染患者和24例非HIV感染患者)慢性根尖周炎患者手术切除的慢性根尖周炎病变组织,组织来源于患者牙齿,所有患者在手术之前未进行牙髓治疗,用光学显微镜对标本进行组织病理学和免疫组化分析。免疫表达分为2级:局灶性至弱与中至强。结果:HIV感染组CD3、CD4、CD8、CD68、IFN-g、IL-6、IL-18表达低于非HIV感染组,TNF-α表达高于非HIV感染组,差异有统计学意义(P<0.05),两组间CD20表达差异无统计学意义(P>0.05)。结论:HIV感染影响患者慢性根尖周炎的炎性因子表达及免疫功能。

Objective:To compare the differences of inflammatory factors and immune function between HIV-infected and non-HIV-infected patients with chronic apical periodontitis.Methods:The excised pathological tissues were obtained from the teeth of 48 patients(24 HIV-infected patients and 24 non-HIV-infected patients)with chronic apical periodontitis.No patients were treated with preoperative endodontic treatment.The samples were histopathologically and immunohistochemically analyzed by an optical microscope.The immune expression was divided into 2 levels:focal to weak and moderate to strong.Results:The expressions of CD3,CD4,CD8,CD68,IFN-g,IL-6,and IL-18 in HIV-infected group were lower than those in non-HIV-infected group,and the expression of TNF-αin infected group was higher than that in non-HIV-infected group(P<0.05).There was no significant difference in CD20 expression between two groups(P>0.05).Conclusion:HIV infection has an effect on the expression of inflammatory factors and immune function in patients with chronic apical periodontitis.