核苷酸结合寡聚化结构域样受体蛋白1、3、6与炎症性肠病的关系

Relationship between the Nucleotide-Binding Oligomerization Domain-Like Receptor Proteins 1,3,and 6 and Inflammatory Bowel Disease

炎症性肠病是一种目前病因尚不完全明确、以肠道受累为主并可伴发肠外表现的一种炎症性疾病,主要包括溃疡性结肠炎和克罗恩病。肠道黏膜受累的部位及损伤程度可被多种因素调控,其中炎症小体发挥了关键作用。核苷酸结合寡聚化结构域样受体蛋白(NLRP)是一类多元化的家庭模式识别受体,是消化系统炎症反应及宿主防御体系的重要介质,能够调节炎症性肠病及结肠炎相关肿瘤的发病率,是肠道疾病中的关键调节因子。目前已有研究显示,其重要成员NLRP 1、NLRP 3、NLRP 6与炎症反应的关系更为密切,可能与白细胞介素-18和白细胞介素-1β的分泌有关。本文着重阐述了NLRP 1、NLRP 3、NLRP 6在炎症性肠病中发挥的作用及其作用机制。

Objective Inflammatory bowel diseases, including Crohn disease and ulcerative colitis, are inflammation disorders charac- terized mainly by intestinal injury that is accompanied by parenteral manifestations. Inflammasome is known to have a key role in the reg- ulation of the location and extent of the disease, but it can be affected by various factors. Nucleotide-binding oligomerization domain-like receptor protein( NLRP) is a type of pattern recognition receptors. The NLRPs are important mediators of the inflammatory response of the digestive and host defense systems;they can regulate the morbidity of inflammatory bowel disease and colitis-related colorectal cancer. Current studies have shown that NLRP1, NLRP3, and NLRP6 are more closely associated with inflammatory response, and thus, may be related to the secretion of interleukin-18 and interleukin-1β. This article focuses on the role of NLRP1, NLRP3, and NLRP6 in inflamma- tory bowel disease and their mechanisms of action.