齐拉西酮治疗单纯型精神分裂症的临床观察

Clinical observation of ziprasidone in the treatment of simple schizophrenia

目的:探讨齐拉西酮治疗以阴性症状为主的单纯型精神分裂症患者的临床效果及安全性。方法:收治单纯型精神分裂症患者60例,随机分为两组,观察组采用齐拉西酮进行治疗,对照组采用舒必利进行治疗,观察对比两组患者的治疗效果以及治疗过程中的不良反应。结果:经治疗,两组患者的阴性症状均明显改善,但齐拉西酮的不良反应较舒必利少而轻。结论:齐拉西酮与舒必利治疗以阴性症状为主的单纯型精神分裂症患者疗效相当,齐拉西酮不良反应少,依从性高,疗效及安全性好。

Objective:To investigate the clinical efficacy and safety of zilacidone in the treatment of simple schizophrenia with negative symptoms.Methods:60 patients with simple schizophrenia were randomly divided into the two groups,they were randomly divided into the two groups,the observation group was treated with ziprasidone and the control group was treated with sulpiride,we observed and compared the therapeutic effect and adverse reactions in the course of treatment between the two groups.Results:After treatment,the negative symptoms of the two groups of patients were significantly improved,but the adverse reaction of zilacidone was less than that of sulpiride.Conclusion:Zilacidone and shubili are effective in the treatment of patients with simple schizophrenia with negative symptoms.Zilacidone has fewer adverse reactions,high compliance,and good efficacy and safety.