地拉罗司有关物质分析方法研究

Study on the Related Substances Method of Deferasirox

地拉罗司是一种新型口服铁螯合剂,它是美国FDA批准的第一个能够常规使用的口服驱铁剂,在欧洲被推荐作为6岁以上地中海贫血铁过载患者的一线用药^([1])。本文采用高效液相色谱法对地拉罗司中的有关物质进行研究,该方法灵敏、准确,可用于主流合成路线下地拉罗司中有关物质的测定。

Deferasirox is a new oral iron chelator.It is the first oral iron chelator approved in USA by FDA.It is also recommended as the initial therapy for patients over the age of 6 years who are suffering from beta-thalassaemia.A HPLC method was developed for the determination of related substances in Dilaros.The method is sensitive and accurate.It can be used for the determination of related substances in Dilaros under the mainstream synthetic route.