脑梗死患者颈动脉斑块的临床观察与治疗初探

Clinical observation and treatment of carotid plaques in patients with cerebral infarction

目的探讨阿托伐他汀钙片对脑梗死患者颈动脉粥样硬化斑块的临床治疗效果。方法选择2017年1月～2018年1月来我院进行治疗的50例脑梗死患者作为此次研究对象,将其分为对照组与观察组,每组25例。对照组采用常规肠溶阿司匹林治疗,观察组给予阿托伐他汀钙片进行治疗,比较两组患者双侧颈动脉斑块积分。结果入院时以及治疗1月后,观察组患者颈动脉斑与对照组比较,差异无统计学意义(P> 0.05)。对照组在治疗3、6月后颈动脉斑块增加,差异有统计学意义(P <0.05)。观察组在治疗3、6月后颈动脉斑块减小,差异有统计学意义(P <0.05)。入院时,观察组患者血脂水平对照组比较,差异无统计学意义(P> 0.05);治疗1、3、6月后,两组患者TC、 TG、 HDL-C、 LDL-C水平均优于入院时,差异有统计学意义(P <0.05)。但观察组患者TC、 TG、 HDL-C、 LDL-C水平显著优于对照组患者,差异有统计学意义(P <0.05)。结论使用阿托伐他汀钙片治疗脑梗死患者颈动脉粥样硬化斑块的临床治疗效果显著,不仅可以稳定甚至减轻动脉粥样硬化,还可以降低患者血脂,值得临床推广应用。

Objective To explore the clinical curative effect of atorvastatin calcium tablets on carotid atherosclerotic plaque in patients with cerebral infarction. Methods 50 patients with cerebral infarction who were treated in our hospital from January 2017 to January 2018 were selected as research objects. They were divided into the control group and the observation group, with 25 cases in each group. The control group was treated with conventional enteric coated aspirin while the observation group was treated with atorvastatin calcium tablets. Scores of bilateral carotid plaques were compared between the two groups. Results There was no significant difference in carotid plaques between the observation group and the control group at admission and 1 month after treatment (P > 0.05). In control group, carotid plaques increased after treatment for 3 and 6 months. The difference was statistically significant (P < 0.05). Carotid plaque decreased in the observation group after treatment for 3 and 6 months. The difference was statistically significant (P < 0.05). On admission, there was no significant difference in blood lipid levels between the observation group and the control group (P > 0.05). After 1, 3, 6 months of treatment, the levels of TC , TG , HDL-C and LDL-C in the two groups were better than those at admission, and the difference was statistically significant (P < 0.05). But the levels of TC, TG, HDL-C and LDL-C in the observation group were significantly higher than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion Atorvastatin calcium tablets in the treatment of carotid atherosclerotic plaque in patients with cerebral infarction have a significant clinical curative effect. It can not only stabilize or even alleviate atherosclerosis, but also reduce blood lipid, which is worthy of clinical promotion and application.