期刊文献+

应用7关节超声评分评价类风湿关节炎达标治疗 被引量:6

Application of 7-joint ultrasound score in evaluation on treat-to-target of rheumatoid arthritis
下载PDF
导出
摘要 目的探讨7关节超声评分在类风湿关节炎达标治疗中的应用价值。方法收集活动期40例类风湿关节炎患者,遵循临床达标治疗原则,分析治疗前后28关节疾病活动度(DAS28)、滑膜炎、肌腱腱鞘炎及7关节超声评分的变化,并对滑膜炎、腱鞘炎及7关节超声评分变化量与DAS28变化量行相关性分析。结果与治疗前相比,类风湿关节炎患者治疗后DAS28、滑膜炎、肌腱腱鞘炎及7关节超声评分均减低,差异均有统计学意义(P均<0.001);治疗前后骨侵蚀差异无统计学意义(P=0.317)。治疗前后滑膜炎、肌腱腱鞘炎及7关节超声评分变化量与DAS28变化量均呈弱正相关(r_s=0.363、0.318、0.317,P=0.021、0.045、0.047)。结论 7关节超声评分可为评价类风湿关节炎达标治疗效果提供参考,但不推荐仅以超声缓解作为达标治疗的检测指标。 Objective To explore the application value of 7-joint ultrasound score in the treat-to-target of rheumatoid arthritis. Methods Totally 40 patients with rheumatoid arthritis in active stage were enrolled. The changes of disease activity score of 28 joints(DAS28), synovitis, tenosynovitis and 7-joint ultrasound score before and after treatment were analyzed in accordance with the principles of clinical standard treatment, and the correlation of changes of synovitis, tenosynovitis, 7-joint ultrasound score and changes of DAS28 were analyzed. Results Compared with those before treatment, DAS28, synovitis, tenosynovitis and 7-joint ultrasound score decreased significantly after escalation therapy(all P<0.001), but changes in bone erosion were not statistically significant(P=0.317). The changes of synovitis, tenosynovitis, 7-joint ultrasound score and DAS28 showed relatively weak correlation(r_s=0.363, 0.318, 0.317, P=0.021, 0.045, 0.047). Conclusion 7-joint ultrasound score can be used to detect changes of disease activity of rheumatoid arthritis, but not yet be advocated as testing index for treat-to-target escalation.
作者 张艳 杜方雪 冯宁 高硕辰 ZHANG Yan;DU Fangxue;FENG Ning;GAO Shuochen(Department of Ultrasound, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China)
出处 《中国医学影像技术》 CSCD 北大核心 2019年第5期745-749,共5页 Chinese Journal of Medical Imaging Technology
基金 河南省医学科技攻关计划项目(201602066)
关键词 关节炎 类风湿 超声检查 达标治疗 7关节超声评分 arthritis,rheumatoid ultrasonography treat-to-target 7-joint ultrasound score
  • 相关文献

参考文献3

二级参考文献50

  • 1Sherine EG, Kaleb M. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases [J]. Arthritis Res Ther, 2009, 11 : 229.
  • 2Zeng QY, Chen R, John D, et al. Rheumatic disease in China [J]. Arthritis Res Tlier, 2008, 10: R17.
  • 3Li R, Sun J, Ren LM, et al: Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing[J]. Rheumatology (Oxford), 2012, 51: 721-729.
  • 4Maradit-Kremers H, Crowson CS, Nicola PJ, et al. Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study[J]. Arthritis Rheum, 2005, 52: 402-411.
  • 5Frostegard J. Atherosclerosis in patients with autoimmune disor- ders[J]. Arterioscler Thromb Vasc Biol, 2005, 25: 1776-1785.
  • 6Panoulas VF, Metsios GS, Pace AV, et al. Hypertension in rheumatoid arthritis[J]. Rheumatology (Oxford), 2008, 4-7: 1286- 1298.
  • 7Dessein PH, Joffe BI, Stanwix A, et al. The acute phase re- sponse does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis [J]. J Rheumatol, 2002, 29: 462-466.
  • 8Mercer LK, Davies R, Galloway JB, et al. Risk of cancer in patients receiving non-biologic disease-modifying therapy for rheumatoid arthritis compared with the UK general population[J]. Rheumatology (Oxford), 2013, 52: 91-98.
  • 9Smitten AL, Simon TA, Hochberg MC, et al. A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis[J]. Arthritis Res Ther, 2008, 10: 45.
  • 10Sichletidis L, Settas L, Spyratos D, et al. Tuberculosis in pa- tients receiving anti-TNF agents despite chemoprophylaxis[J]. Int J Tuberc Lung Dis, 2006, 10: 1127-1132.

共引文献52

同被引文献63

引证文献6

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部