脑梗死急性期S100-β蛋白和cTnI的水平变化

CHANGES OF S100-β PROTEIN AND CTNI LEVELS IN ACUTE PHASE OF CEREBRAL INFARCTION

目的探讨脑梗死急性期S100-β蛋白和cTnI的水平变化及应用价值。方法选择126例脑梗死急性期患者为研究组,另选同期健康检查的80例中老年人作为对照组。检测对照组体检时及研究组入院1、3、7、14 d时血清S100-β蛋白和cTnI的水平。结果研究组血清S100-β蛋白及出现先升高后降低的趋势(F=186.27,952.63;P<0.01),cTnI水平至入院14 d恢复至对照组水平(q=2.02,P>0.05),其他仍高于对照组(q=3.44～69.96,P<0.05);二者水平有随疾病程度加重而升高的趋势(F=259.30,541.09;P<0.05)。结论 S100-β蛋白和cTnI的水平可作为判断脑梗死患者病情程度的标志物。

Objective To investigate the changes and application value of S100-β protein and cTnI in acute phase of cerebral infarction. Methods A total of 126 patients with acute cerebral infarction were enrolled in the study group, and 80 elderly patients with concurrent health examinations were selected as the control group. Serum levels of S100-β protein and cTnI were measured at the time of physical examination and at 1, 3, 7 and 14 days after admission in the study group. Results The serum S100-β protein in the study group increased first and then decreased ( F =186.27,952.63;P <0.01). The level of cTnI returned to the same level the control group on the 14th day after admission ( q =2.02, P >0.05). Others were still higher than the control group ( q =3.44~69.96, P <0.05);the levels of both increased with the severity of the disease ( F =259.30, 541.09;P <0.05). Conclusion The levels of S100-β protein and cTnI can be used as markers to determine the severity of cerebral infarction patients.