孕妇血清中同型半胱氨酸、维生素B_(12)、叶酸的表达及分析

Expression and Analysis of Homocysteine, Vitamin B_(12) and Folic Acid in Serum of Pregnant Women

目的分析比较孕妇血清中同型半胱氨酸、叶酸和维生素B_(12)的具体表达方式。方法收集本院2016年7月—2017年12月间接受的孕妇62例,分析孕妇血清中HCY、叶酸与维生素B_(12)的水平、临床指标间的相互关系、孕妇血糖、血压与三者水平的相关性。结果年龄大于30岁的孕妇叶酸含量和维生素B_(12)分别为(100.00±15.89)nmol/L、(357.08±25.91)nmol/L,小于30岁的为(9.25±2.01)nmol/L和(453.31±28.59)nmol/L(t=8.325,P=0.000 0,t=18.876,P=0.000 0)。孕妇血清中的HCY、叶酸和维生素B_(12)水平与孕妇的年龄、早产症状和妊娠并发症有密切联系(P<0.05)。结论对孕妇进行血清指标检测可以及时有效识别高危孕妇,孕妇在孕期多补充叶酸与维生素B_(12)可以有效改善其妊娠结局。

Objective To analyze and compare the specific expression patterns of homocysteine,folic acid and vitamin B12 in maternal serum.Methods A total of 62 pregnant women admitted to our hospital from July 2016 to December 2017 were enrolled.The levels of HCY,folic acid and vitamin B12 in serum,the relationship between clinical indicators,blood glucose,blood pressure and blood levels of pregnant women were analyzed.Results Folic acid content and vitamin B12 in pregnant women over 30 years old were(100.00±15.89)nmol/L,(357.08±25.91)nmol/L,and(9.25±2.01)nmol/L and(453.31±28.59)nmol/L were less than 30 years old(t=8.325,P=0.000 0;t=18.876,P=0.000 0).The levels of HCY,folic acid and vitamin B12 in maternal serum were closely related to the age of pregnant women,premature birth symptoms and pregnancy complications(P<0.05).Conclusion The detection of serum indicators in pregnant women can identify high-risk pregnant women in a timely and effective manner.Pregnant women who supplemented with folic acid and vitamin B12 during pregnancy can effectively improve their pregnancy outcomes.