摘要
目的探讨原发性高血压患者合并非酒精性脂肪肝(NAFLD)与脂联素(APN)及胰岛素抵抗(IR)的关系。方法选取2015年5月~2016年6月潍坊市寒亭区人民医院收治的67例原发性高血压患者作为研究对象,根据是否合并有NAFLD分为脂肪肝组(n=33)和非脂肪肝组(n=34)。比较两组患者的体重指数(BMI)、空腹血糖(FBG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、谷丙转氨酶(ALT)等指标水平,用酶联免疫吸附法(ELISA)测定法检测两组患者血清APN浓度,放免法测定空腹胰岛素(FINS),采用稳态模型(HOMA-IR)法评估IR,并进行比较。结果脂肪肝组的BMI、FBG、TC、TG、LDH-C、ALT、FINS、HOMA-IR均高于非脂肪肝组,而脂肪肝组的HDL-C、APN水平低于非脂肪肝组,差异有统计学意义(P<0.05)。APN与SBP、DBP、TG、HbA1c、FINS、HOMA-IR均成负相关(r=-0.48、-0.36、-0.44、-0.31、-0.32、-0.34,P<0.05)。结论原发性高血压患者合并NAFLD与APN及IR密切相关。
Objective To investigate the relationship among insulin resistance,adiponectin(APN)and non-alcoholic fatty liver disease(NAFLD)in patients with essential hypertension(EH).Methods A total of 67 patients with EH treated in Weifang Hanting District People's Hospital from May 2015 to June 2016 were selected as the subjects,and divided into EH+NAFLD group(with NAFLD,n=33)and EH group(without NAFLD,n=34).The indicators including body mass index(BMI),fasting blood glucose(FBG),total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),alanine aminotransferase(ALT)were compared between the two groups.The APN was determined by enzyme-linked immunosorbentassay(ELISA),fasting insulin(FINS)were determined by radioimmunoassay,and IR was assessed by homeostasis model assessment-insulin resistance(HOMA-IR)test.Results The levels of BMI,FBG,TC,TG,LDH-CH,ALT,FINS,HOMA-IR in EH+NAFLD group were higher than those in EH group,and the levels of HDL-C and APN in EH+NAFLD group were lower than those in EH group(P<0.05).The level of ANP was negatively correlated with SBP,DBP,TG,HbA1c,FINS and HOMA-IR in patients with EH(r=-0.48,-0.36,-0.44,-0.31,-0.32,-0.34,P<0.05).Conclusion NAFLD in patients with EH is closely related to APN and Insulin resistance.
作者
刘国勤
于瑞霞
LIU Guo-qin;YU Rui-xia(Department of Cardiology,Hanting People's Hospital of Weifang City in Shandong Province,Weifang 261100,China)
出处
《中国当代医药》
2019年第13期37-39,49,共4页
China Modern Medicine
基金
山东省潍坊市卫生和计划生育委员会科研项目(2015080)
关键词
高血压
非酒精性脂肪肝
脂联素
胰岛素抵抗
Hypertension
Non-alcoholic fatty liver disease
Adiponectin
Insulin resistance