尿毒症腹膜透析患者血清高敏C反应蛋白、白蛋白、前白蛋白、β_2微球蛋白水平变化

Changes of Serum High-sensitivity C-reactive Protein, Albumin, Prealbumin and β_2 Microglobulin in Uremic Peritoneal Dialysis Patients

目的探究尿毒症腹膜透析患者血清高敏C反应蛋白、白蛋白、前白蛋白、β_2微球蛋白水平变化。方法方便抽取2017年1—6月该中心尿毒症腹膜透析患者189例作为该次观察组,另选取同期收入健康体检者100名作为对照组,两组患者均采用ELISA法检测血清,并采用全自动生化分析仪检测C反应蛋白、白蛋白、前白蛋白、β_2微球蛋白水平,分析各项指标相关性。结果观察组Hs-CRP、β_2-M分别为(6.24±1.41)mg/L、(4.24±1.12)mg/L高于对照组两组差异有意义(t=26.823,25.183,P<0.05),Alb、PA分别为(30.25±6.47)g/L、(0.27±0.11)g/L低于对照组两组差异有统计学意义(t=-12.771,-3.561,P<0.05)。观察组治疗前后各项水平比较中,治疗前Hs-CRP、β_2-M高于治疗后,治疗前Alb、PA水平低于治疗后,差异有统计学意义(P<0.05)。β_2-M与Hs-CRP呈正相关,Alb、PA水平与Hs-CRP呈负相关。结论尿毒症腹膜透析患者血清Hs-CRP、β_2-M升高,血清Alb、PA、降低。因此,尿毒症腹膜透析患者存在明显微炎症状态,与机体营养状况较差以及尿毒症毒素体内蓄积有关。

Objective To explore the changes of serum high-sensitivity C-reactive protein,albumin,prealbumin andβ2 microglobulin in uremic peritoneal dialysis patients.Methods From January to June 2017,189 patients with uremia peritoneal dialysis in our center were selected as the observation group,and 100 patients with healthy physical examination at the same time were selected as the control group.The ELISA method was used to detect serum in both groups.The automatic biochemical analyzer was used to detect the levels of C-reactive protein,albumin,prealbumin andβ2 microglobulin,and the correlation of various indicators was analyzed.Results The Hs-CRP andβ2-M in the observation group were(6.24±1.41)mg/L and(4.24±1.12)mg/L,respectively,which were significantly different from the control group(t=26.823,25.183,P<0.05),and Alb and PA were(30.25±6.47)g/L and(0.27±0.11)g/L were statistically significant lower than the control group(t=-12.771,-3.61,P<0.05).Before and after treatment,the levels of Hs-CRP andβ2-M before treatment were higher than those after treatment.The levels of Alb and PA before treatment were lower than those after treatment(P<0.05).β2-M was positively correlated with Hs-CRP,and Alb and PA levels were negatively correlated with Hs-CRP.Conclusion Serum Hs-CRP andβ2-M were elevated in uremic peritoneal dialysis patients,and serum Alb,PA,and decreased.Therefore,uremic peritoneal dialysis patients have a significant micro-inflammatory state,which is related to the poor nutritional status of the body and the accumulation of uremic toxins.