一锅法合成氨基噻唑类化合物

氨基噻唑类化合物具有较强的生理活性和药理活性,并且是良好的有机合成中间体。该研究直接利用苯环上含有不同取代基的苯基乙酮作为反应底物,二甲基亚砜作为绿色的氧化剂和苯基硫脲发生一锅法反应,以较高的收率得到了一系列氨基噻唑类化合物。为了优化反应条件,我们同时探索了在其他氧化剂和溶剂存在下对该反应进度的影响。

Aminothiazole compounds have strong physiological and pharmacological activities and are good intermediates for organic synthesis.In this study,a series of aminothiazoles were synthesized from acetophenone with different substituents on the benzene ring,dimethyl sulfoxide as green oxidant and phenylthiourea in one pot reaction with high yield.In order to optimize the reaction conditions,we also explored the effect of other oxidants and solvents on the reaction progress.