江苏省赣榆、阜宁地区自然人群3项乙型肝炎血清学标志物分布特征

Distribution characteristics of three hepatitis B virus serological markers among population in Ganyu and Funing area of Jiangsu province

目的了解16～60岁人群3项乙型肝炎血清学标志物(HBVM)模式分布特征。方法 2014年,分别对江苏省赣榆、阜宁接受HBVM 3项指标检测的志愿者无菌采集静脉血5mL,采用ELISA试剂盒检测乙型肝炎表面抗原(HBsAg)、表面抗体(HBsAb)和核心抗体(HBcAb)。结果赣榆区、阜宁县分别有4 446名和5 102名志愿者入选本研究,赣榆区志愿者HBsAg携带率为4.32%,阜宁县为3.92%,赣榆区HBsAg阳性率随年龄增长呈递减趋势(P=0.018),阜宁县HBsAg阳性率随年龄增长呈递增趋势(P<0.001)。3项筛查结果共形成HBVM模式8种,赣榆以模式1、模式7、模式4和模式3为主,阜宁县以模式7和模式4为主;同一县区不同性别间HBVM模式构成比差异均有统计学意义(P<0.001)。结论赣榆、阜宁两县区均处于乙肝病毒中流行区,HBVM模式构成比有所不同,性别是HBsAg携带率的主要影响因素。

Objective To investigate distribution characteristics of three hepatitis B virus serological markers(HBVM)among population aged from 16 to 60 years.Methods In 2014,5 mL venous blood was collected from each volunteer in Ganyu and Funing of Jiangsu province,the three HBVM of HBsAg,HBsAb and HBcAb were detected by ELISA kit.Results A total of 4 446 and 5 102 volunteers were enrolled in GanYu district and in Funing county,respectively.The prevalence rates of HBsAg among population in GanYu district and Funing county were 4.32%and 3.92%,respectively.The positive rate of HBsAg showed an descending trend in Ganyu district(P=0.018)and ascending trend in Funing county(P<0.001)upon age.A total of 8 models of three HBVM were formed.Model 1,7,4 and 3 were dominant models in Ganyu district;while model 7 and 4 were dominant models in Funing county.There were significant differences in the proportion of HBVM patterns between different genders in the same county(P<0.001).Conclusion Ganyu district and Funing county were medium prevalence area for HBV,whose constituent ratios of HBVM distribution models were different.Gender was an important influence factors of the prevalence of HBsAg.