桉柠蒎肠溶软胶囊联合血必净注射液治疗慢性阻塞性肺疾病急性加重期临床效果观察

Observation of the Clinical Effect of Eucalyptol Limonene Pinene Enteric Soft Capsule Combined with Xuebijing Injection in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的观察桉柠蒎肠溶软胶囊联合血必净注射液治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease, AECOPD)的临床效果。方法选取AECOPD 150例,随机将其分为A组、B组和C组3组各50例,A组给予AECOPD常规治疗,B组在AECOPD常规治疗基础上给予痰热清注射液治疗,C组在AECOPD常规治疗基础上给予桉柠蒎肠溶软胶囊联合血必净注射液进行治疗,观察比较3组临床疗效、治疗前后肺功能指标、治疗前后血清炎性因子水平及治疗过程中不良反应发生情况。结果治疗后3组总有效率、肺功能指标、血清炎性因子水平及治疗过程中不良反应总发生率总体比较差异均有统计学意义(P<0.05)。治疗后,总有效率及肺功能指标C组明显高于A组和B组,B组明显高于A组;血清炎性因子水平C组明显低于A组和B组,B组明显低于A组,差异有统计学意义(P<0.05)。治疗过程中,不良反应总发生率C组明显低于A组和B组,B组明显低于A组,差异有统计学意义(P<0.05)。结论桉柠蒎肠溶软胶囊联合血必净注射液应用于AECOPD不仅可以提高临床治疗效果,还可以改善患者肺功能指标,降低患者血清炎性因子水平,且不良反应发生率较低。

Objective To observe the clinical effect of Eucalyptol Limonene Pinene Enteric Soft Capsule combined with Xuebijing Injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). MethodsA total of 150 cases of AECOPD were selected and randomly divided into three groups: Group A (n=50), Group B (n=50) and Group C (n=50). Group A received conventional treatment of AECOPD, Group B received Tanreqing injection on the basis of conventional treatment of AECOPD, and Group C was given Eucalyptol Limonene Pinene Enteric Soft Capsule combined with Xuebijing injection on the basis of conventional treatment of AECOPD. The clinical efficacy, pulmonary function indexes before and after treatment, serum levels of inflammatory factors before and after treatment and the occurrence of adverse reactions in the course of treatment were observed and compared among the three groups. ResultsThere were significant differences in total effective rate, pulmonary function indexes, serum levels of inflammatory factors and total incidence of adverse reactions among the three groups after treatment ( P <0.05). After treatment, the total effective rate and pulmonary function indexes in Group C were significantly higher than those in Group A and B, and those in Group B were significantly higher than those in Group A. The serum levels of inflammatory factors in Group C were significantly lower than those in Group A and B, and those in Group B were significantly lower than those in Group A, suggesting significant differences ( P <0.05). In the course of treatment, the total incidence of adverse reactions in Group C was significantly lower than that in Group A and B, and that in Group B was significantly lower than that in Group A, indicating significant differences ( P < 0.05). ConclusionEucalyptol Limonene Pinene Enteric Soft Capsule combined with Xuebijing injection in the treatment of AECOPD can not only improve the clinical efficacy, but also improve the pulmonary function indexes of patients and reduce the serum levels of inflammatory factors, with a low incidence of adverse reactions.