褪黑素对核苷酸结合寡聚域样受体蛋白3炎性小体的影响及其机制

Effects of Melatonin on Nucleotides Binding Oligomeric Domain Receptor Protein 3 Inflammatory Corpuscle and Its Mechanisms

随着畜牧业集约化生产水平的不断提高,动物炎症带来的经济损失逐渐受到重视。细胞表面Toll样受体(TLRs)可以通过活化胞浆内核转录因子-κB(NF-κB),诱导核苷酸结合寡聚域样受体蛋白3(NLRP3)炎性小体表达,加剧炎症反应。本文就NLRP3炎性小体与炎症疾病,褪黑素对TLRs、NF-κB和NLRP3炎性小体的作用以及炎症对动物生产的影响作一综述。

With the continuous improvement of intensive production level of animal husbandry,the economic losses caused by animal inflammation have been paid more and more attention.Toll-like receptors on cell surface can induce the expression of nucleotide-binding oligomeric domain-like receptor protein-3 inflammatory corpuscle by activating intracytoplasmic nuclear transcription factor-kappa B,and aggravate the inflammatory response.This article reviews the nucleotide-binding oligomeric receptor protein-3 inflammatory corpuscle and inflammatory diseases,the effects of melatonin on Toll-like receptors,nuclear transcription factor-kappa B and nucleotide-binding oligomeric receptor protein-3 inflammatory corpuscle,and the effects of inflammation on animal production.