温针灸配合药物治疗老年脑梗死的疗效观察

Observation on the Efficacy of Warm Needling plus Medication in Treating Cerebral Infarction in the Elderly

目的观察温针灸配合药物治疗老年脑梗死的临床疗效。方法将100例老年脑梗死患者随机分为治疗组52例和对照组48例。治疗组采用温针灸配合依达拉奉注射液静脉滴注治疗,对照组采用单纯依达拉奉注射液静脉滴注治疗。观察两组治疗前后各项氧化应激指标[丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)]、炎症反应指标[白细胞介素-6(IL-6)、肿瘤坏死因子-?(TNF-?)、C反应蛋白(CRP)]、神经功能缺损评分(NHISS评分)及Fugl-Meyer量表评分(FMA评分)的变化情况,并比较两组临床疗效及不良反应发生率。结果治疗组总有效率为96.2%,对照组为75.0%,两组比较差异具有统计学意义(P<0.05)。两组治疗后各项氧化应激指标、炎症反应指标、NHISS评分和FMA评分与同组治疗前比较,差异均具有统计学意义(P<0.05)。治疗组治疗后各项氧化应激指标、炎症反应指标、NHISS评分和FMA评分与对照组比较,差异均具有统计学意义(P<0.05)。治疗组不良反应发生率为7.7%,对照组为25.0%,两组比较差异具有统计学意义(P<0.05)。结论温针灸配合依达拉奉注射液静脉滴注是一种治疗老年脑梗死的有效方法,可调节患者氧化应激反应,抑制炎症因子水平表达,改善患者认知功能,促进其肢体功能恢复。

Objective To observe the clinical efficacy of warm needling plus medication in treating cerebral infarction in the elderly.Method One hundred elderly patients with cerebral infarction were randomized into a treatment group of 52 cases and a control group of 48 cases.The treatment group was intervened by warm needling plus intravenous drip of edaravone injection,while the control group was intervened by intravenous drip of edaravone injection alone.The indicators of oxidative stress [malondialdehyde(MDA),reactive oxygen species(ROS)and superoxide dismutase(SOD)],indicators of inflammatory response [interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)],neurological deficit score [National Institute of Health stroke scale(NHISS)score] and Fugl-Meyer assessment(FMA)score in the two groups were observed before and at the end of the treatment,and the clinical efficacies and the incidence of adverse reactions were compared.Result The total effective rate was 96.2% in the treatment group and 75.0% in the control group,and there was a statistically significant difference between the two groups(P<0.05).The indicators of oxidative stress and inflammatory response,NHISS score and FMA score all showed a significant change after the treatment in the two groups(P<0.05).After the treatment,the indicators of oxidative stress and inflammatory response,NHISS score and FMA score in the treatment group were significantly different from those in the control group(P<0.05).The incidence of adverse reactions was 7.7% in the treatment group and 25.0% in the control group,and there was a statistically significant difference between the two groups(P<0.05).Conclusion Warm needling plus intravenous drip of edaravone injection is an effective method in treating elderly cerebral infarction.It can regulate oxidative stress in the patients,inhibit the inflammatory factor expression,improve their cognitive function and promote the recovery of limb function.