双氢青蒿素抗癌药理作用机制的研究进展

Research progress on anti-tumor mechanisms of dihydroartemisinin

双氢青蒿素是青蒿素的一种重要衍生物,是我国自行研发的抗疟新药。近年来,人们发现双氢青蒿素不但具有抗疟活性,而且具有良好的抗肿瘤效果,被认为是前景良好的抗肿瘤药。因此,综述目前双氢青蒿素抗肿瘤作用发生机制、靶点和通路的研究进展,主要包括癌细胞凋亡、内质网应激、癌细胞生长增殖、侵袭转移、肿瘤多药耐药以及细胞氧化损伤等方面。为抗肿瘤的基础研究、新药物研发以及药物设计提供参考和依据。

Dihydroartemisinin(DHA),an important artemisinin derivative,is one of new anti-malarial medicines developed by Chinese scientists.In recent years,it was reported that DHA is a promising anti-cancer medicine besides its extraordinary antimalarial activities.This article overviews the mechanisms,targets and signaling pathways of DHA based on the recent studies published in English and Chinese literatures.Specifically,this article covers some important topics,such as apoptosis,endoplasmic reticulum stress,the growth,proliferation and invasion of cancer cells,multidrug resistance and oxidative damage,in order to provide a better understanding to the anti-cancer effects of DHA and information for new drug development and design.