尖锐湿疣患者采用派特灵结合肌注干扰素治疗的临床效果

Patients with condyloma acuminata combined with the treatment of interferon

目的探究尖锐湿疣患者采用派特灵结合肌注干扰素治疗的临床效果。方法选取2015年1月至2017年1月榆林市第一医院诊治的60例尖锐湿疣患者作为研究对象。根据入院先后实施分组,对照组30例,给予单纯干扰素肌注治疗;观察组30例,在对照组治疗方法的基础上加用派特灵治疗。对两组患者治疗前后的免疫学指标、不良反应发生情况以及临床治疗效果进行综合评价。结果观察组患者治疗后白细胞介素2(IL-2)、肿瘤坏死因子(TNF-a)以及CD_(4+)/CD_(8+)免疫学指标均得到显著改善,与对照组比较差异具有统计学意义(P<0.05);观察组治疗后不良反应率为6.7%,较对照组的26.7%低,差异具有统计学意义(P<0.05);观察组治疗后有27例患者显示有效,占90.0%,显著高于对照组的66.7%,差异具有统计学意义(P<0.05)。结论尖锐湿疣患者采用派特灵结合肌注干扰素治疗,能够促进患者免疫功能改善,减少不良反应的发生,效果显著,值得推广应用。

ObjectiveTo explore the clinical effect of the treatment of patients with condyloma acuminata combined with the treatment of interferon. MethodsFrom January 2015 to January 2015 in our hospital for treatment of 60 patients with condyloma acuminatum were as the research object, according to hospital has implemented group, 30 cases of control group given interferon alone intramuscular injection treatment;In the observation group, 30 patients were treated with petronic therapy on the basis of control group, and the immunological indexes, adverse reactions and clinical therapeutic effects of the two groups before and after treatment were comprehensively evaluated. ResultsThe observation group after treatment in patients with interleukin 2 (IL - 2), tumor necrosis factor (TNF-a) and CD4 +/ CD8 + immunological indexes were improved significantly, compared with the control group there is statistical significance difference (P<0.05);After treatment, the adverse reaction rate was 6.7%, which was lower than 26.7% in the control group (P<0.05), and there was statistical significance. After treatment, 27 patients were shown to be effective, accounting for 90.0%, significantly higher than 66.7% in the control group, and the difference between the two groups was statistically significant (P<0.05). ConclusionsThe treatment of patients with condyloma acuminata combined with the treatment of interferon, can promote the improvement of immune function, reduce the occurrence of adverse reactions, and the effect is remarkable, and it is worth populating and applying.