干扰素注射联合5-氟尿嘧啶局部外用治疗巨大尖锐湿疣的临床研究

Clinical study of interferon injection combined with local external application of 5-Fu in the treatment of giant condyloma acuminate

目的研究干扰素注射联合5-氟尿嘧啶(5-Fu)局部外用治疗巨大尖锐湿疣的价值,为临床治疗提供参考依据。方法选取2016年10月至2017年10月鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)诊治的164例尖锐湿疣患者作为研究对象,按照随机数表法将其分为观察组和对照组。观察组84例患者给予干扰素注射联合5-Fu局部外用治疗,对照组80例患者采用LEEP刀联合干扰素治疗。比较治疗后两组患者的临床疗效、复发率和不良反应,以及伤口结痂、愈合、人乳头状瘤病毒(human papillomavirus,HPV)清除时间及疣体清除情况。结果治疗后,观察组患者总有效率为97.6%,高于对照组患者的75.0%,其差异具有统计学意义(P<0.05);观察组患者的复发率为4.8%,低于对照组患者的22.5%,其差异具有统计学意义(P<0.05);两组患者均出现红斑、水肿、糜烂等不良反应,其差异无统计学意义(P>0.05)。观察组患者伤口结痂、愈合、HPV清除的时间分别为(3.2±1.2)d、(7.3±1.3)d和(32.5±12.5)d,均小于对照组患者相应的时间,其差异均具有统计学意义(均P<0.05)。治疗后,观察组患者在第1周、第2周疣体清除率为77.7%和100.0%,均高于对照组患者的58.0%和85.6%,其差异均有统计学意义(均P<0.05)。结论干扰素注射联合5-Fu局部外用治疗巨大尖锐湿疣,临床疗效显著,疣体清除率高,且复发率低,并发症较少,患者伤口结痂、愈合、HPV清除均可以得到有效改善,值得临床借鉴。

ObjectiveTo study the value of interferon injection combined with 5- fluorouracil (5-Fu) topical external application in the treatment of giant condyloma acuminatum (CA), so as to provide reference for its clinical treatment. Methods164 patients with giant CA in Huangshi Central Hospital from December 2016 to December 2017 were randomly divided into observation group (n=84) and control group (n=80). The observation group was treated with interferon injection combined with 5-Fu topical external application while the control group was treated with LEEP knife combined with interferon treatment. The clinical efficacy, recurrence rate and adverse reaction of the two groups after treatment were compared, as well as the scab, healing, HPV clearance and verrucous clearance rate. ResultsAfter treatment, the total efficiency of the observation group (97.6%) was higher than that of the control group (75.0%), with statistically significant difference (P<0.05). The recurrence rate in the observation group (4.8%) was lower than that in the control group (22.5%), with statistically significant difference (P<0.05). There were adverse reactions in both groups including erythema, edema and erosion, without statistically significant difference between the two groups (P>0.05). The time of scab, healing and HPV clearance in the observation group was (3.2±1.2) d,(7.3±1.3) d, and (32.5±12.5) d respectively, which were all shorter than those in the control group, with statistically significant differences (all P<0.05). The verrucous clearance rate in the observation group at the first and second week after treatment was 77.7% and 100.0% respectively, higher than the control group of 58.0% and 85.6%, with statistically significant differences (all P<0.05). ConclusionsInterferon injection combined with 5-Fu topical external application is of remarkable effect in treating patients with giant CA, with high verrucous clearance rate, low recurrence rate and low incidence of complication, which can significantly improve the scab, healing and HPV clearance, hereby worthy of clinical application.