兔VX2肿瘤模型的研究进展

Research Progress of Rabbit VX2 Tumor Model

兔VX2肿瘤模型是目前比较常用的建立在较大动物身上的移植瘤模型,因其体型大、容易复制,在外科手术、影像学及介入治疗等研究中广泛应用。VX2肿瘤模型的建立方法包括肿瘤细胞悬液接种和肿瘤组织块移植接种,根据移植部位的不同可以建立多种类型的肿瘤模型,研究人员可以根据自己的研究目的选用合适的类型。随着影像设备的普及和新兴局部治疗方法的应用,采用兔VX2肿瘤模型的研究越来越多。本文从VX2细胞的来源及生物学特性、兔VX2肿瘤模型的建立方法及类型、研究应用等方面进行综述。

The rabbit VX2 tumor model is commonly used as a xenograft tumor model in large animals, which is also widely used in surgical operation, imageology and interventional therapy because of its body type and easy replication. The methods of establishing rabbit VX2 tumor model include injection of cell suspension and inoculation of tumor tissue block. The tumor models can be established differently depending on the site of the transplant. Researchers can select suitable tumor models for their own purposes. With the popularity of imaging equipment and the application of the emerging local treatment methods, more and more studies have been conducted using the rabbit VX2 tumor model. This paper reviewed the source of VX2 cells, biological characteristics, methods of tumor models and research applications.