经导管前列腺动脉栓塞治疗前列腺增生疗效观察

Effect of transcatheter prostatic arterial embolization for treatment of prostatic hyperplasia

目的评价对不耐受或不欲接受外科手术且药物治疗效果差的前列腺增生患者行经导管前列腺动脉栓塞(PAE)的安全性及有效性。方法对15例经药物治疗无效且伴有中重度下尿路梗阻(LUTS)症状的前列腺增生患者行PAE治疗。观察术后并发症情况,并分别于术后1、3、6、12个月复查国际前列腺症状评分(IPSS)及生活质量(Qol)评分,比较术前与术后不同时间患者IPSS、Qol评分的统计学差异。结果 15例PAE术后均未出现严重并发症,仅有轻度下腹部疼痛或尿道烧灼感(3/15,20.00%)、穿刺处淤斑(1/15,6.67%)及不同程度发热(4/15,26.67%)。患者术前及术后不同时间IPSS、Qol评分差异均有统计学意义(F=8.90、15.97,P均<0.01);术后1、3、6、12个月患者IPSS、Qol评分均较术前明显减低(P均<0.01)。结论对于不耐受或不欲接受外科手术且药物治疗效果差的前列腺增生患者,PAE治疗安全、有效。

Objective To assess the safety and efficacy of prostatic arterial embolization (PAE) for prostatic hyperplasia patients intolerant or reluctant to surgery and with poor effects of drug therapy.Methods A total of 15 patients with prostatic hyperplasia and moderate-severe lower urinary tract symptoms (LUTS) who were uncontrollable of drug therapy were treated with PAE.The postoperative complications were observed.The international prostate symptom score (IPSS) and quality of life (Qol) were obtained at 1,3,6 and 12 months during following-up after surgery.Statistical analysis was used to compare IPSS and Qol before and after treatment.Results No serious complication occurred after PAE,while mild abdominal pain or burning sensation of urinary tract (3/15,20.00%),ecchymosis at the puncture site (1/15,6.67%) and different degrees of fever(4/15,26.67%)were observed.There were significant differences of IPSS and Qol among different time points before and after treatment ( F =8.90,15.97,both P <0.01).Pairwise comparison showed IPSS and Qol at 1,3,6 and 12 months after treatment were significantly lower than those before treatment (all P <0.01).Conclusion PAE is safe and effective for treatment of prostatic hyperplasia patients intolerant of or reluctant to surgery and with poor effects of drug therapy.