群体感应系统调控乳酸菌细菌素合成的研究进展

Advances in the regulation of bacterial synthesis by quorum sensing system

乳酸菌细菌素具有广谱的抑菌活性,但其合成量低,限制了行业应用。群体感应是细胞间的通信过程,细菌通过感知信号分子浓度变化,调控相关的生物学过程。三组分系统在调控细菌素合成的过程中发挥了核心作用。本文中,笔者综述了调控乳酸菌细菌素合成的三组分系统的组成、Ⅰ类和Ⅱ类细菌素合成调控的基因与结构的差异性以及细菌密度和共培养等因素对细菌素的合成的影响,以阐明乳酸菌素合成的群体感应调控机制,对于其在食品、生物和医疗领域的应用都有重要的意义。

Lactic acid bacteria bacteriocin has a broad spectrum of antibacterial activity,but its synthesis is low,which limits the industrial application.Quorum sensing is a cell-to-cell communication process in which bacteria regulate related biological processes by sensing changes in signal molecule concentrations.The three-component system plays a key role in the regulation of bacteriocin synthesis.This paper reviews the composition of a three-component system that regulates the synthesis of bacteriocins in lactic acid bacteria,the differences of genes and structures in the regulation of the synthesis for class Ⅰ and class Ⅱ bacteriocins,and the effects of bacterial density and co-culture on the synthesis of bacteriocin.It is of great significance to elucidate the quorum sensing regulation mechanism of lactobacilli synthesis for its application in food,biology and medicine.