加巴喷丁联合盐酸羟考酮对晚期癌因性疼痛患者的效果及对其疼痛介质的影响

Effect of Gabapentin Combined with Oxycodone Hydrochloride on Patients with Advanced Cancer-induced Pain and its Effect on Pain Media

目的分析晚期癌因性疼痛患者治疗中加巴喷丁联合盐酸羟考酮的效果、对疼痛介质的影响。方法选取76例晚期癌因性疼痛患者随机分成参照组37例和观察组39例。参照组给予盐酸羟考酮治疗,观察组给予加巴喷丁联合盐酸羟考酮治疗。比较用药前后两组疼痛评分及疼痛介质水平。结果用药前两组疼痛数字量表(NRS)评分,5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)水平比较,差异无统计学意义(P>0.05);用药后观察组NRS评分、5-HT、DA、NE分别为(2.30±0.75)分、(682.05±85.93)ng/L、(13254.51±2546.01)ng/L、(468.63±52.74)ng/L,低于参照组的(4.21±0.63)分、(821.17±71.02)ng/L、(15862.01±2634.51)ng/L、(497.30±53.59)ng/L,且两组各项指标均较治疗前降低,差异均有统计学意义(P<0.05)。结论晚期癌因性疼痛患者治疗中加巴喷丁联合盐酸羟考酮可减轻疼痛、降低疼痛介质水平。

Objective To analyze the effect of gabapentin combined with oxycodone hydrochloride in the treatment of patients with advanced cancer-induced pain and its effect on pain media.Methods 76 patients with advanced cancer-induced pain were randomly divided into a reference group of 37 patients and an observation group of 39 patients.The reference group was given oxycodone hydrochloride treatment, and the observation group was given gabapentin combined with oxycodone hydrochloride. The pain scores and pain media levels were compared between the two groups before and after medication.Results There were no significant differences in the pain digital scale (NRS) scores, serotonin (5-HT), dopamine (DA) and norepinephrine (NE) levels between the two groups before treatment (P>0.05). The NRS scores, 5-HT, DA, and NE in the post-observation group were (2.30±0.75),(682.05±85.93) ng/L,(13254.51±2546.01) ng/L,(468.63±52.74) ng/L,respectively,which was lower than the reference group(4.21±0.63),(821.17±71.02) ng/L,(15862.01±2634.51) ng/L,(497.30±53.59) ng/L,and the indexes of the two groups were lower than before treatment,the differences were statistically significant (P<0.05).Conclusion Gabapentin combined with oxycodone hydrochloride in patients with advanced cancer-induced pain can reduce pain and reduce the level of pain media.