菖蒲郁金汤联合针刺星状神经节治疗缺血性脑卒中的疗效作用

Efficacy of the Changpu Yujin decoction plus acupuncture on ICS

目的:研究菖蒲郁金汤联合针刺星状神经节治疗缺血性脑卒中(Ischemic Cerebral Stroke,ICS)的疗效作用。方法:选择2017年1-12月肇庆市中医院脑病科收治的86 例痰瘀阻络型ICS 患者,以随机数字表法分为观察组及对照组,各43例。对照组患者予卒中单元临床路径治疗。治疗组患者在对照组基础上给予菖蒲郁金汤及针刺星状神经节治疗。两组均连续治疗14 d。观察两组患者的临床症状与体征改善情况,采用中医证候评分量表(Traditional Chinese Medicine Syndrome Scores,TCMSS)与美国国立卫生院卒中量表(National Institutes of Health Stroke Scale,NIHSS)进行评价。检测两组患者血清5-羟色胺(5-hydroxytryptamine,5-HT)、同型半胱氨酸(Homocysteine,HCY)、肿瘤坏死因子(Tumor Necrosis Factor,TNF)-α和白细胞介素(Interleukin,IL)-6 的浓度水平。结果:观察组患者总有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后TCMSS、NIHSS 均明显低于对照组,差异有统计学意义(P<0.05)。观察组治疗后血清5-HT 浓度水平明显高于对照组,差异有统计学意义(P<0.05)。再者,观察组治疗后血清 HCY、TNF-α、IL-6 浓度水平明显低于对照组,差异有统计学意义(P<0.05)。结论:菖蒲郁金汤联合针刺星状神经节能够明显改善ICS 患者的临床症状,促进神经功能的恢复,其作用可能与调节5-HT、HCY、TNF-α与IL-6 的表达有关。

Objective:To observe efficacy of the Changpu Yujin decoction (菖蒲郁金汤)plus acupuncture on ICS.Methods:86 cases were divided into two groups,43 cases in each.The control group took clinical pathway of stroke unit.The observation group was given the Changpu Yujin decoction plus acupuncture more.Results:The total efficiency,TCMSS,NIHSS and Concentration of serum 5-HT were better in the observation group.And HCY,TNF-α,IL-6 were lower than the control group.Conclusion:The Changpu Yujin decoction plus acupuncture can improve ICS and neuromechanism,and the efficacy may be related with regulation of 5-HT,HCY,TNF-α,IL-6.