中西医结合降低尿血酸治疗2型糖尿病合并NAFLD的临床研究

A clinical study on treating type 2 diabetes mellitus with NAFLD by the integrative medicine

目的:探讨西医基础上加粉萆薢治疗2 型糖尿病(Type 2 Diabetes Mellitus,T2DM)患者合并非酒精性脂肪性肝病(Non-Alcoholic Fatty Liver Disease, NAFLD)的可行性。方法:将110 例T2DM 合并NAFLD 患者随机分为两组,其中西药组给予二甲双胍治疗,中西药组在二甲双胍治疗基础上加服粉萆薢,疗程为一个月,记录两组血尿酸水平,比较两组糖脂水平及肝功能,评价临床效果。结果:与西药组相比,中西药组治疗后血尿酸(Serum Uric Acid,SUA)水平得到改善更优(P<0.01)。两组治疗后血清总胆固醇(Total Cholesterol,TC)、甘油三脂(Triglyceride,TG)、低密度脂蛋白胆固醇(Low Density Lipoproteincholesterd,LDL-C)指标和空腹血糖(Glucose,GLU)、空腹胰岛素(Fasting insulin,Fins)指标相比差异显著(P<0.01),此外,中西药组肝功能恢复更有效(P<0.01)。西药组有效患者33 例(60.0%),中西药组有效患者47 例(85.5%),两组治疗有效率相比,差异显著(P<0.01)。结论:二甲双胍作联合粉萆薢可有效降低患者尿血酸水平,改善了患者糖脂水平和肝功能,对T2DM 合并NAFLD 疾病具有良好临床治疗效果。

Objective:To investigate the feasibility of treating T2DM with NAFLD with Fen Bixie (粉萆薢) plus Western medicine. Methods:110 patients with T2DM with NAFLD were randomly divided into two groups.The western medicine group was treated with metformin,and the Chinese and Western medicine group was treated with Fen Bixie more.Results:Compared with the western medicine group,the SUA level in the Chinese and Western medicine group was significantly improved after treatment (P<0.01).There were significant differences in TC,TG,and LDL-C blood lipid parameters and GLU and Fins blood glucose levels after treatment between the two groups (P<0.01).In addition,the liver function improvement in Chinese and Western medicine groups was significantly better (P<0.01). The effective number of patients in the Western medicine group was 33 cases,and the effective rate was 60.0%.The effective number of patients in the Chinese and Western medicine group was 47 cases,and the effective rate was 85.5%(P<0.01).Conclusion:Metformin plus Fen Bixie on type 2 diabetes patients with non-alcoholic fatty liver disease show a good effect,can effectively reduce the level of uric acid, improve glycolipid levels and liver function.