以三氟乙酸及其衍生物为三氟甲基源的三氟甲基化反应研究进展

Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF3-Sources

含有三氟甲基基团的有机分子中常常表现出独特的物理和化学性质,具有非常广泛的应用.三氟乙酸及其衍生物具有廉价、易得、稳定等优点,并且反应的副产物是二氧化碳,是理想的三氟甲基化试剂,具有广阔的应用前景.综述了以三氟乙酸及其衍生物为三氟甲基源的三氟甲基化反应的最新研究进展,主要包括C-X(X=Br,I)键、C-H键,C=X(X=C,O)的三氟甲基化反应,对反应的相关机理进行了论述.

Organic molecules containing tri fluoromethyl groups often exhibit unique physical and chemical properties,and have found extensive applicatio ns.Tri fluoroacetic acid and its derivatives have advantages including low cost,ready availability and high stability.Furthermore,CO2 is the byproduct.Therefore,trifluoroacetic acid and its derivatives are ideal trifluoromethylating reagents,and have great applicatio n potentials.The progress of tri fluoromethylation reactions using tri fluoroacetic acid and its derivatives as CF3-sources is reviewed,including the reactions of C-X(X=Br and I),C-H,and C=X(X=C,O).The mechanisms are also introduced.