安神定志汤治疗儿童多发性抽动症的疗效观察

Clinical Observation on Anshen Dingzhi Decoction in Treating Children with Tourette's Syndrome

【目的】探析在"恢复中轴圆运动"思想指导下的安神定志汤治疗儿童多发性抽动症的临床疗效。【方法】将60例多发性抽动症患儿随机分为治疗组和对照组,每组各30例。对照组给予静灵口服液治疗,治疗组给予安神定志汤加减治疗,连续治疗6周并随访半年。观察2组患儿治疗前后耶鲁综合抽动严重程度量表评分(包括抽动频率、抽动次数和抽动强度评分)的变化情况和治疗组患儿血清微量元素的变化情况,评价2组治疗后疗效和随访疗效。【结果】(1)治疗6周后,治疗组的总有效率为96.67%,明显高于对照组的66.56%,差异有统计学意义(P<0.05)。(2)治疗后,2组患儿耶鲁综合抽动严重程度量表各维度评分均较治疗前下降(P<0.05),且治疗组对各维度评分的降低作用均优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,治疗组患儿血铅含量下降,血锌、铁含量升高,差异均有统计学意义(P<0.05或P<0.01)。(4)共有48例有效病例获得随访,治疗组的复发率为7.1%,明显低于对照组的25.0%,差异有统计学意义(P<0.05)。【结论】在"恢复中轴圆运动"思想指导下的安神定志汤治疗儿童多发性抽动症有较好的疗效。

Objective To explore the clinical effect of Anshen Dingzhi Decoction prescribed according to restoringcentral-axis Qi circular movement for the treatment of Tourette’s syndrome in children. Methods A total of 60 cases of children with Tourette’s syndrome were randomly divided into treatment group(30 cases)and controlgroup(30 cases). The control group was treated with Jingling Oral Liquid,and the treatment group was treatedwith Anshen Dingzhi Decoction orally. The treatment lasted for 6 continuous weeks and a follow-up for half a yearwas carried out. Before and after treatment, the scores of the frequency, times, and severity of tics wereevaluated with Yale Global Tic Severity Scale(YGTSS),and the serum contents of trace elements were detected.The clinical efficacy of the two groups was evaluated after treatment and after the follow-up. Results(1)The totaleffective rate of the treatment group(96.67%)was higher than that of the control group(66.56%),the differencebeing significant(P<0.05).(2)After treatment, the scores of the frequency, times, and severity of ticsevaluated with YGTSS in the two groups were decreased(P<0.05 compared with those before treatment),and thedecrease in the treatment group was superior to that in the control group(P<0.05).(3)After treatment, thecontents of serum lead in the treatment group were lower while the levels of zinc and ferritin were higher than thosebefore treatment, the differences being significant(P<0.05 or P<0.01).(4)The results of follow-up for 48 cases showed that the recurrence rate in the treatment group was 7.1%, lower than that in the control group(25.0%),and the difference was signficiant(P<0.05). Conclusion Anshen Dingzhi Decoction prescribed accordingto restoring central-axis Qi circular movement is effective for the treatment of Tourette’s syndrome in children.