乳腺浸润性微乳头状癌临床病理及诊治的研究进展

Research progress of clinicopathology, diagnosis and treatment of invasive micropapillary carcinoma of the breast

目的探讨乳腺浸润性微乳头状癌(IMPC)的临床病理特点及诊治。方法检索近年国内外相关文献,综述IMPC的临床特点、病理特征及诊治的研究进展。结果 IMPC发病率低,多混合发生,与浸润性导管癌的临床表现基本相似,只有经病理学检查才能确诊;典型的病理学特点是癌细胞"极向反转"及"主、间质分离现象"。结论 IMPC是乳腺浸润癌的一种特殊分型,镜下形态独特,同时具有高脉管侵袭性及高淋巴结转移率,恶性程度高、预后差等特点,临床上需要引起足够的重视。

Objective To investigate the clinicopathological features, diagnosis and treatment of invasive micropapillary carcinoma (IMPC) of the breast. Method The relevant literatures at home and abroad in recent years about the clinical features, pathological features and diagnosis and treatment of IMPC were reviewed. Results IMPC is in low incidence and mostly in mixture. Because the clinical manifestations of IMPC and invasive ductal carcinoma of breast are basically similar, only the typical pathological features in pathological examination can confirm the diagnosis as “inside-out growth pattern” and “morula-like clusters of cancer cells surrounded by clear stromal spaces”. Conclusions IMPC is a special subtype of breast invasive carcinoma, which should be pay enough attention to it in clinic due to its unique microscopic morphology, high vessel invasiveness and high lymph node metastasis rate, high malignancy, poor prognosis and so on.