新生儿坏死性小肠结肠炎患者的甲状腺激素水平的分析研究

Analysis of Thyroid Hormone Levels in Neonatal Necrotizing Enterocolitis

目的分析新生儿坏死性小肠结肠炎(NEC)中甲状腺激素的水平。方法选取我院2017年3月到2018年3月收治的130例患有NEC的早产儿作为观察组,另选取同期130例无NEC的早产儿作为对照组,采用化学发光免疫分析法(CLIA)检测并比较两组患儿的甲状腺激素水平。结果观察组患儿甲状腺激素水平显著低于对照组,差异有统计学意义;观察组患儿TSH水平低于对照组,差异无统计学意义;而观察组组内的患儿分期越严重,甲状腺激素水平越低下,差异有统计学意义。结论甲状腺激素在NEC患儿中的表达呈低水平,且NEC病情越严重,下降幅度越大,故通过监测甲状腺功能可为临床评估NEC病情严重程度提供一定的帮助。

Objective To analyze the levels of thyroid hormones in neonatal necrotizing enterocolitis(NEC).Methods 130 preterm infants with NEC,from March 2017 to March 2018 in our hospital,were selected as the observation group,while 130 preterm infants without NEC were selected as the control group.And the thyroid hormone levels in two groups were detected and compared by chemiluminescence Immunoassay(CLIA).Results The thyroid hormone levels in the observation group were significantly lower than that in the control group,statistically significant.The thyroid stimulating hormone(TSH)level in the observation group was lower than that in the control group,no statistically significant.In observation group,the more serious the grades was,the lower the thyroid hormone level was,statistically significant.Conclusion The expression of thyroid hormone in children with NEC is low,and the more serious of NEC is,the greater it decline.Therefore,monitoring the thyroid function can provide some help for clinical evaluation of the severity of NEC.