非编码RNA与肝衰竭关系的研究进展

Research progress on the relationship between non-coding RNA and liver failure

肝衰竭是常见的危重疾病,临床上无良好的早期诊断指标和治疗方法。研究显示,以微小RNA(miRNA)和长链非编码RNA(lncRNA)为代表的非编码RNA(ncRNA)不仅可以作为肝衰竭的早期诊断指标,也在肝衰竭炎性反应、肝细胞死亡和肝细胞再生过程中发挥着重要的调控作用,同时ncRNA参与的表观遗传调控也参与肝衰竭的发生和发展。现就miRNA和lncRNA与肝衰竭的关系进行综述,以期为肝衰竭的诊断与治疗寻找新的作用靶点。

Liver failure is a familiar severe disease,with no good clinical early diagnostic indicators and treatment methods.Studies have shown that non-encoding RNA(ncRNA)characterized by microRNA(miRNA)and long non-coding RNA(lncRNA)can be used not only as an early diagnostic indicator of liver failure,but also play a key regulatory role in an inflammatory response to liver failure,hepatocyte death and hepatocyte regeneration.Simultaneously,the epigenetic regulation of ncRNA also participates in the initiation and progression of liver failure.This article reviews the relationship between miRNA,lncRNA,and liver failure to find new targets for the diagnosis and treatment of liver failure.