阿利吉仑联合雷米普利治疗轻中度原发性高血压的疗效观察

Observation on efficacy of aliskiren combined with ramipril in the treatment of mild to moderate essential hypertension

目的探讨阿利吉仑联合雷米普利治疗轻中度原发性高血压的临床疗效。方法选取轻中度原发性高血压患者102例(2017年11月～2018年6月),按随机数字表分为研究组(n=51)与对照组(n=51)。常规干预基础上对照组予雷米普利治疗,研究组在对照组基础上加用阿利吉仑治疗,疗程均为8周。统计两组治疗前及疗程结束后血压[舒张压(DBP)、收缩压(SBP)]、生活质量(SF-36)、不良反应。结果疗程结束后,两组SBP、DBP低于治疗前,且研究组低于对照组(P<0.001),两组SF-36分值较治疗前增高,且研究组高于对照组(P<0.001);研究组不良反应发生率(13.73%)与对照组(9.80%)比较差异无统计学意义(P>0.05)。结论雷米普利联合阿利吉仑治疗轻中度原发性高血压,可有效调节血压,改善患者生活质量,且不会增加不良反应发生风险,安全性较好。

Objective To investigate the clinical effects of aliskiren combined with ramipril on the treatment of mild to moderate essential hypertension.Methods A total of 102 patients with mild to moderate essential hypertension admitted to hospital from November 2017 to June 2018 were enrolled in the study,and all patients were divided into study group(n=51)and control group(n=51)according to randomized digital table.On the basis of routine intervention,the control group were treated with ramipril,and the study group were given aliskiren based on the control group.Both groups were treated for 8 weeks.And then,blood pressure[diastolic blood pressure(DBP),systolic blood pressure(SBP)],quality of life(SF-36),and adverse reactions were counted before and after the treatment.Results After the course of treatment,SBP and DBP in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.001);the SF-36 scores of the two groups were higher than those before treatment,and that of the study group was higher than that of the control group(P<0.001);the incidence of adverse reactions in the study group was 13.73%,and that the control group was 9.80%,difference was not statistically significant between the two groups(P>0.05).Conclusion Ramipril combined with aliskiren in the treatment of mild to moderate essential hypertension can effectively regulate the blood pressure of patients and improve their quality of life without increasing the risk of adverse reactions,which has high safety.