艾司西酞普兰治疗精神分裂症后抑郁障碍的疗效分析

Analysis of efficacy of escitalopram in treatment of post-schizophrenia depression

目的探讨艾司西酞普兰对精神分裂症后抑郁障碍患者的治疗效果。方法选取2016年1月至2018年6月住院的51例精神分裂症后抑郁障碍患者作为研究对象,采用区组随机化分组的方法,将其分为研究组(n=26)和对照组(n=25),在维持原有抗精神病药物治疗的基础上,研究组患者服用艾司西酞普兰治疗,对照组服用帕罗西汀治疗。比较两组患者治疗前后的汉密尔顿抑郁量表(HAMD)评分及治疗效果。结果两组临床疗效比较差异无统计学意义(P>0.05)。治疗前,两组患者的HAMD评分比较差异无统计学意义(P>0.05);研究组和对照组在治疗第2周末、第4周末、第6周末的HAMD评分均明显下降,随时间推移逐渐降低,在治疗第2周末研究组HAMD评分低于对照组(P<0.05),治疗第6周末,两组HAMD评分比较差异无统计学意义(P>0.05)。经过4周抗抑郁治疗,研究组不良反应发生率为19.23%(5/26),对照组不良反应发生率为36.00%(9/25)。两组不良反应发生率比较差异无统计学意义(χ~2=1.799,P>0.05)。结论艾司西酞普兰治疗精神分裂症后抑郁障碍效果良好,疗效与帕罗西汀相当,但起效更迅速。

Objective To investigate the therapeutic effect of escitalopram in patients with post-schizophrenic depression.Methods From January 2016 to June 2018,51 hospitalized patients with post-schizophrenic depression were selected as study subjects,and randomized grouping was used to divide them into study group(n=26)and control group(n=25).On the basis of maintaining the original antipsychotic therapy,the study group were treated with escitalopram and the control group were treated with paroxetine.And then,Hamilton Depression Scale(HAMD)scores before and after treatment as well as therapeutic effects were compared between the two groups.Results The difference of therapeutic effects between the two groups was not statistically significant(P>0.05).There was no statistically significant difference in HAMD scores between the two groups before treatment(P>0.05).The HAMD scores of the study group and the control group decreased significantly at the end of the 2nd,4th and 6th week of treatment,and gradually decreased over time.At the end of the 2nd week of treatment,the HAMD score of the study group was lower than that of the control group(P<0.05),and at the end of the 6th week of treatment,there was no statistically significant difference in the HAMD scores between the two groups(P>0.05).After 4 weeks of antidepressant treatment,the incidence of adverse reactions was 19.23%(5/26)in the study group and 36.0%(9/25)in the control group.There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^2=1.799,P>0.05).Conclusion Escitalopram is effective in the treatment of post-schizophrenic depressive disorder,its efficacy is comparable to paroxetine,but its effect is more rapid.