从抑制炎性因子和提高免疫功能方面探究小儿热速清颗粒治疗小儿疱疹性咽峡炎的机制

Study on the mechanism of pediatric resuqing granules in the treatment of children with herpangina from inhibition of inflammatory factors and enhancement of immune function

目的:观察小儿热速清颗粒治疗小儿疱疹性咽峡炎对炎性因子和免疫功能的影响。方法:收治疱疹性咽峡炎患儿72例,随机分为两组,各36例。对照组应用清开灵注射液治疗,观察组采取清开灵注射液联合小儿热速清颗粒进行治疗。比较两组治疗总有效率、治疗前及治疗5 d的白细胞介素-10(IL-10)、人干扰素(IFN-γ)、IgA、IgG、IgM水平、不良反应总发生率。结果:观察组治疗总有效率94.44%,显著高于对照组的77.78%,差异有统计学意义(P<0.05)。两组治疗后血清IL-10、IgG、IgA与IgM水平均较治疗前显著升高、IFN-γ水平较治疗前显著降低(P<0.05)。观察组治疗后的血清IL-10、IgG、IgA与IgM水平显著高于对照组,IFN-γ水平显著低于对照组(P<0.05)。结论:小儿热速清颗粒治疗小儿疱疹性咽峡炎可有效抑制炎性因子,改善机体免疫,强化治疗效果,安全可靠。

Objective:To observe the effect of pediatric resuqing granules on inflammatory factors and immune function in the treatment of children with herpangina.Methods:72 cases with herpangina were selected,they were randomly divided into the two groups with 36 cases in each group.The control group was treated with Qingkailing injection,while the observation group was treated with Qingkailing injection combined with pediatric resuqing granule.The total effective rate,the levels of IL-10,IFN-γ, IgA,IgG,IgM before treatment and 5 days of after treatment and the total incidence of adverse reactions were compared between two groups.Results:The total effective rate of the observation group was 94.44%,which was significantly higher than 77.78% in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of serum IL-10,IgG,IgA and IgM in both groups were significantly higher than those before treatment,and the levels of IFN-γ were significantly lower than those before treatment(P<0.05).After treatment,the serum levels of IL-10,IgG,IgA and IgM in the observation group were significantly higher than those in the control group,and the levels of IFN-gamma were significantly lower than those in the control group(P< 0.05).Conclusion:The pediatric resuqing granules in the treatment of children with herpangina can effectively inhibit inflammatory cytokines,improve immunity,the treatment has been strengthened,safe and reliable.