Sam68蛋白在晚期伴转移性宫颈癌患者中的表达水平及与其远期预后的相关性分析

Expression of Sam68 Protein in Patients with Advanced Metastatic Cervical Cancer and Its Correlation with Long-term Prognosis

目的探讨Sam68蛋白在晚期伴转移性宫颈癌患者中的表达水平及与其远期预后的相关性。方法选取2008年5月—2014年12月我院收治宫颈癌患者144例为研究对象,取晚期伴转移性宫颈癌患者的病理组织84例为A组、早期宫颈癌病理组织60例为B组,癌旁正常的宫颈组织84例为C组。记录Sam68蛋白在3组中的表达情况及其与晚期伴转移性宫颈癌患者预后的关系。结果 A组和B组癌组织中的Sam68蛋白阳性表达率均高于C组,且A组高于B组(P<0.05)。A组中Sam68蛋白阳性患者3年生存率低于Sam68蛋白阴性患者(P<0.05)。肿瘤分化程度越低、临床分期越高、淋巴结转移数目越多、治疗前血红蛋白过低、采用单纯放疗和Sam68蛋白阳性的晚期伴转移性宫颈癌患者3年生存率均显著降低(P<0.05)。临床分期Ⅳa期、治疗前血红蛋白过低、单纯放疗和Sam68蛋白阳性期均为影响晚期伴转移宫颈癌患者预后的独立危险因素(P<0.05)。结论 Sam68蛋白在晚期伴转移宫颈癌患者癌组织中表达水平较高,且其表达阳性是导致该类患者远期生存率较低的独立危险因素,可作为评估远期预后的有效指标之一。

Objective To investigate expression of Sam68 protein in patients with advanced metastatic cervical cancer and its correlation with long-term prognosis. Methods A total of 144 patients with cervical cancer admitted during May 2008 and December 2014 were recruited in the study, in which 84 cases of pathological tissues from patients with advanced cervical cancer associated by metastasis were selected as group A, and 60 cases of pathological tissues from patients with early cervical cancer were selected as group B, and then 84 cases of normal cervical tissues adjacent to cancer were selected as group C. Expressions of Sam68 protein and its relationship with prognosis of patients with advanced metastatic cervical cancer were recorded among three groups. Results Positive expression rates of Sam68 protein in group A and B were significantly higher than that in group C, and the rate in group A was significantly higher than that in group B ( P <0.05). In group A, 3-year survival rate of patients with positive Sam68 protein was significantly lower than that of patients with negative Sam68 protein. The 3-year survival rate of advanced metastatic cervical cancer patients with lower degree of tumor differentiation, higher clinical stage, greater number of lymph node metastasis, lower level of hemoglobin before treatment, radiotherapy alone and positive Sam68 protein, showed significantly decreased ( P <0.05). Clinical stage Ⅳa, low level of hemoglobin before treatment, radiotherapy alone and positive phase of Sam68 protein were independent risk factors affecting prognosis of patients with advanced metastatic cervical cancer ( P <0.05). Conclusion Sam68 protein has higher expression in cancer tissues of patients with advanced metastatic cervical cancer, and its positive expression is an independent risk factor for low long-term survival rate of patients with advanced metastatic cervical cancer, and therefore it can be used as one of effective indicators for evaluating long-term prognosis.