ICU获得性肌无力的影响因素分析

Analysis on influencing factors of ICU acquired myasthenia

目的分析ICU获得性肌无力的影响因素。方法回顾性分析601例患者资料,按是否并发ICU获得性肌无力将患者分成两组,比较两组患者相关资料并进行多元Logistic回归分析。结果 601例患者中并发ICU获得性肌无力319例;Logistic回归分析结果显示,ICU获得性肌无力的危险因素较多,包括年龄、性别、休克指数、APACHEⅡ评分、严重脓毒症、多器官功能不全综合征、急性肾损伤、血浆高渗性、镇静剂、神经肌肉阻滞剂、制动、机械通气时间、ICU住院时间;每日唤醒是ICU获得性肌无力的保护因素。结论 ICU患者发生ICU获得性肌无力原因复杂,每日唤醒对ICU获得性肌无力有一定预防价值。

Objective To analyze the influencing factors of ICU acquired myasthenia. Method Analyze the information of 601 patients retrospectively and divide them into ICU acquired myasthenia group and non-ICU acquired myasthenia group. Compare the related information of two groups and make multivariate Logistic regression analysis. Result 319 among 601 patients are complicated with ICU acquired myasthenia. Logistic regression analysis shows that there are many influencing factors of ICU acquired myasthenia, including age, gender, shock index, APACHEⅡ score, severe sepsis, multiple organ dysfunction syndrome, acute kidney injury, hypertonic plasma, sedative, neuromascular blocking agent, brakes, mechanical ventilation time and ICU time. Daily interruption of sedation is a protective factor of ICU acquired myasthenia. Conclusion The causes of ICU acquired myasthenia for ICU patients are complicated. Daily interruption of sedation has a certain preventive value for ICU acquired myasthenia.