氟草烟仲辛酯的合成研究

Study on Synthesis of Fluroxypyr Meptyl

研究了以五氯吡啶为原料,经氟化,氨基化,羟基化,缩合,共四步反应制得氟草烟仲辛酯,通过添加分子筛,缩短反应步骤,探究最佳反应条件。结果表明,采用A型分子筛,氨化反应温度为0～10℃,缩合温度为100～150℃,氟草烟仲辛酯的收率可达到73.5%。

Synthesis of fluroxypyr meptyl through fluoridation, amination, hydroxylation and condensation with pentachloropyridine as starting material was studied. The synthetic steps were shortened by adding molecular sieve and the optimized reaction conditions were explored. The results show that when the molecular sieve is type-A, the temperature of fluoridation is 0~10 ℃ and the temperature of amination is 100~150 ℃, the yield of fluroxypyr meptyl was 73.5%.