甲基苯丙胺所致精神障碍的相关因素分析

The analysis of correlated factors of methamphetamine-induced psychosis

目的:探讨影响甲基苯丙胺所致精神障碍的病程和症状严重程度的可能因素。方法:采用回顾性研究方法,中了解人口学信息、甲基苯丙胺使用情况及简明精神病评定量表(BPRS)评分,共61例患者纳入分析,使用多元线性回归(进入法)进行统计分析。结果:精神障碍病程与甲基苯丙胺使用时间正相关(B=2. 422,P=0. 002),BPRS总分与开始使用毒品的年龄负相关(B=-0. 493,P=0. 028)。结论:甲基苯丙胺滥用时间、开始使用甲基苯丙胺的年龄可以作为甲基苯丙胺所致精神障碍严重程度的预测因素。

Objective: The objective of this study was to determine the correlated factor of methamphetamine-induced psychosis ( MIP) in patients with methamphetamine ( MA) dependence.Methods: By adopting the method of retrospective study,general demographic and clinical data were collected from medical records when patients were admitted to Shenzhen Kangning Hospital. Brief Psychiatric Rating Scale( BPRS) scores were collected from medical records . 61patients were included to the analysis. All the data were analyzed by multivariable linear regression( enter).Results: The duration of MIP was positively correlated with periods of MA exposure ( B = 2. 422,P = 0. 002). BPRS total score was negatively correlated with age of onset of MA use ( B =- 0. 493,P = 0. 028).Conclusion: The longer period exposure of MA predicts the longer that psychosis is likely to last. The earlier one start to abuse MA the more severe MIP symptoms they produced.