Colonfile基因检测对结直肠癌化疗及靶向药物使用的临床意义研究

Study on clinical significance of Colonfile gene detection for chemotherapy and targeted drug use in colorectal cancer

目的探讨可菲(Colonfile)基因检测对结直肠癌化疗及靶向药物使用的临床指导意义。方法 12例行术后化疗的结直肠癌患者,按随机数字表法并参考基本资料分为观察组及对照组,每组6例。观察组行基因检测法,结合检测结果编制完善的个治疗计划;对照组不进行基因检测。观察比较两组患者化疗后无进展生存期(PFS)及不良反应发生情况。结果研究组患者的PFS为(23.64±1.29)个月,显著长于对照组的(19.62±1.15)个月,差异具有统计学意义(P<0.05)。化疗后,观察组患者腹泻、白细胞减少、血尿素氮升高和肝功能损害发生率分别为16.7%、16.7%、16.7%、33.3%,显著低于对照组的83.3%、66.7%、66.7%、83.3%,差异具有统计学意义(P<0.05);两组患者的血肌酐升高、心脏毒性和神经毒性发生率比较差异无统计学意义(P>0.05)。结论对结直肠癌患者实施基因检测,结合检测的结果编制治疗计划,能够延长患者生存期,预防不良反应,具有推广价值。

Objective To discuss the clinical guidance significance of Colonfile gene detection for chemotherapy and targeted drug use in colorectal cancer.Methods A total of 12 patients with colorectal cancer who received chemotherapy after operation were divided into research group and control group according to random number table and basic data,with 6 cases in each group.In the observation group,gene testing was performed,and a complete treatment plan was worked out based on the results of the test.In the control group,gene testing was not performed.The progression-free survival(PFS)and adverse reactions after chemotherapy between the two groups was observed and compared.Results The research group had significantly longer PFS as(23.64±1.29)months than(19.62±1.15)months in the control group,and the difference was statistically significant(P<0.05).After chemotherapy,the research group had significantly lower incidence of diarrhea,leukopenia,elevated blood urea nitrogen and liver dysfunction respectively as 16.7%,16.7%,16.7%and 33.3%than 83.3%,66.7%,66.7%and 83.3%in the control group,and the difference was statistically significant(P<0.05).Both groups had no statistically significant difference in incidence of increased serum creatinine,cardiotoxicity and neurotoxicity(P>0.05).Conclusion Implementation of gene detection for colorectal cancer patients can compile treatment plans based on the results of detection,prolong the survival time of patients and prevent adverse reactions.It has promotion value.