摘要
CD73又称5'-核苷酸酶,普遍存在人体多种细胞,是通过糖基-磷酰肌醇介导连接在胞膜上的糖蛋白。CD73有水解酶活性,可降解5'-磷酸腺苷成腺苷,进而通过腺苷与各种腺苷受体亚型作用发挥血管生成、旁分泌和免疫抑制等作用;此外CD73可发挥非酶作用,介导细胞间结合和信号传递。CD73与肿瘤、心肌损伤、脑损伤、糖尿病、弓形虫入侵、系统性红斑狼疮和器官移植等多种临床疾病相关,影响疾病的发生发展,CD73及其水解产生的腺苷与腺苷受体作用,影响机体的生理和病理过程。本文综述近年来CD73的基础和临床研究,以明晰CD73基础研究和临床应用的联系,加快CD73的临床应用。
CD73, also known as 5'-nucleotidase, is a ubiquitous glycoprotein linked to the cell membrane via GPI. CD73 has hydrolase activity, which can degrade adenosine 5'-phosphate into adenosine, and then exert the effects of angiogenesis, paracrine and immunosuppression through the interaction of adenosine and various adenosine receptor subtypes. In addition, CD73 can play a non-enzymatic role in mediating cell-to-cell binding and signal transduction. CD73 is associated with many diseases, such as tumors, myocardial injury, brain injury, diabetes mellitus, Toxoplasma invasion, systemic lupus erythematosus, organ transplantation and so on. Adenosine and adenosine receptors produced by CD73 and its hydrolysis affect the physiological and pathological processes of the body. This article reviews the basic and clinical research of CD73 in recent years, and the relationship between basic research and clinical application of CD73.
作者
王琰
赵育洁
李琼
郭志坤
Wang Yan;Zhao Yujie;Li Qiong;Guo Zhikun(Department of Cardiology,Zhengzhou Seventh People's Hospital,Zhengzhou 450000,China;Henan Key Laboratory of Medical Tissue Regeneration,Xinxiang Medical University,Xinxiang 453000,China)
出处
《中华细胞与干细胞杂志（电子版）》
2019年第1期58-64,共7页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
国家自然科学基金(81570268)
河南省重点攻关项目(15210231011)
关键词
CD73
肿瘤
心肌损伤
脑损伤
弓形体感染
器官移植
CD73
Tumor
Myocardial injury
Brain injury
Toxoplasma infection
Organ transplantation
