儿童血小板聚集在单纯肥胖儿童中的表达及与血栓素的相关性研究

Expression of Platelet Aggregation in Children with Simple Obesity and Its Correlation with hromboxane

目的:探讨儿童血小板聚集在单纯肥胖儿童中的表达及与血栓素的相关性研究。方法:选取2016年5月-2017年5月来我院检查的肥胖儿童45例作为研究组,选取同一时期来院检查的健康儿童45名作为健康对照组,分析血栓素与血小板凝聚在肥胖儿童体内的水平变化,以及其相关性。结果:研究组患儿的血小板1秒凝聚率和5秒凝聚率明显高于对照组(P<0.05);研究组患儿总胆固醇(TC)、低密度胆固醇(LDL)水平明显高于对照组(P<0.05),研究组高密度胆固醇(HDL)明显低于对照组(P<0.05);研究组患儿血栓素B2(TXB2).β-血小板球蛋白(β-TG)水平明显高于对照组(P<0Q5),研究组患儿前列环素分解产物(6-酮-PGF1α)水平明显低于对照组(P<0.05);研究组患儿血清中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及超敏C反应蛋白(hs-CRP)水平高于对照组(P<0.05)。结论:在肥胖儿童体内血脂水平会明显升高,血栓素的表达明显升高,进而加快血小板的凝聚速率,使患儿体内炎性因子升高,增加血栓形成概率,因此,积极有效的预防儿童肥胖是降低或避免心血管疾病发生率的关键。

Objective: This study aims to explore the expression of platelet aggregation in children with simple obesity and its con-elation with thromboxane. Methods: A total of 45 obese children who were admitted to the Hospital from May 2016 to May 2017 were enrolled as the study group. 45 healthy children who were admitted to the Hospital during the same period were selected as healthy control gi-oup. The changes of thromboxane and platelet aggregation in obese children and their correlation were analyzed. Results: The 1 second aggregation rate and 5 second aggregation rate of platelet in the study group were significantly higher than those in the control group (P<0.05). The levels of total cholesterol (TC) and low density cholesterol (LDL) in the study group were significantly higher than those in the control group (P<0.05). The level of high-density cholesterol (HDL) in the study group was significantly lower than the control group (P<0.05). The levels of thromboxane B2 (TXB2) and p-platelet globulin (β-TG) in the study group were significantly higher than that of the control group (P<0.05), and the level of prostacyclin breakdown product (6-keto-PGF1α) in the study group was significantly lower than that in the control group (P<0.05). The levels of serum interleukin-6 (IL-6), tumor necrosis factor-α(TNF -α) and high-sensitivity C-reactive protein (hs-CRP) in the study group were shown to be higher than those in the control group (P<0.05). ConclUSIOn: Obese children are with increased blood lipid level and increased expression of thromboxane, which will accelerate the aggregation rate of platelets, increase the inflammatory factors and increase the probability of thrombosis. Therefore, preventing childhood obesity can help reduce or avoid the incidence of cardiovascular disease.